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Therapeutics Delivery and Cellular Engineering

Electrospinning is a straightforward and robust method to produce nanofibers with the potential to incorporate therapeutics in a simple, rapid, and reproducible process. Drugs can be embedded in the fiber through dissolution or dispersion in the polymer solution for single spinneret electrospinning. On the other hand, coaxial spinneret allows spatially selective compartmentalization of materials in one single fibers, where either the sensitive therapeutics (such as growth factors) can be stabilized inside the core or co-delivery of different therapeutics in a temporally controlled manner.

Our developed biocompatible nanofibric scaffolds synergise the nanostructural induction and the bioactives signalling to affect cellular behaviours, such as gene knockdown, cell adhesion and migration, proliferation and stem cell differentiation.