Lecture by: Peter Johansen
Title: ”Experimental Cardiovascular Biomechanics”
Place: Gustav Wieds Vej 10C, 8000 Aarhus C, Building 3130, Room 303.
This talk gives an overview of ongoing projects in CAVE Lab. Common for all projects are that they are anchored in clinical problems and challenges and therefore conducted in close collaboration with cardiac surgeons and interventional cardiologists. The general approach is to create in vitro models that can mimic the physiology surrounding different devices, implants, and procedures.
Lecture by: Thomas Lykke-Møller Sørensen
Title: ”Highlight(s) from EMBO/EMBL symposium on Mechanobiology”
Place: Gustav Wieds Vej 10C, 8000 Aarhus C, Building 3130, Room 303.
Lecture by: Frederik Høbjerg Svejsø
Title: ”Anti-EpCAM Conjugated Melt-Electrowritten Microfibrous Filter for Capturing and Culturing Circulating Tumor Cells”
Place: Gustav Wieds Vej 10C, 8000 Aarhus C, Building 3130, Room 303.
This presentation will focus on my Master's thesis, where I am utilizing melt-electrowriting to fabricate porous filters of polycaprolactone (PCL). The fiber surface is subsequently conjugated with an anti-EpCAM antibody to allow for affinity-based capture of rare circulating tumor cells (CTCs) from a liquid biopsy, i.e. a blood sample. Due to the biocompatibility of PCL, the caught CTCs will be cultured ex vivo directly on the filter and the formed clusters may contain information useful for personalized medicine.
Master Student
Lecture by: Pernille Ommen Andersen
Title: ”Development of a targeted drug delivery system for Staphylococcus aureus biofilm infections”
Place: Gustav Wieds Vej 10C, 8000 Aarhus C, Building 3130, Room 303.
Conventional antibiotic treatment is inadequate for eradication of bacterial biofilm infections as only sublethal concentrations can be administered safely to patients. A potential solution to this challenge is targeted drug delivery.
In my PhD study, we tailored an aptamer-targeted liposomal drug delivery system that accumulates in S. aureus biofilm and delivers a combination of antibiotics locally inside the biofilm. In this presentation I will show the results and discuss what we learned from the study.
Lecture by: Peter Johansen
Title: ”Experimental Cardiovascular Biomechanics”
Place: Gustav Wieds Vej 10C, 8000 Aarhus C, Building 3130, Room 303.
This talk gives an overview of ongoing projects in CAVE Lab. Common for all projects are that they are anchored in clinical problems and challenges and therefore conducted in close collaboration with cardiac surgeons and interventional cardiologists. The general approach is to create in vitro models that can mimic the physiology surrounding different devices, implants, and procedures.
Lecture by: Camilla Jessen
Title: ”Establishment and Characterization of Polymicrobial Inter-kingdom three-species biofilm models mimicking the microenvironment of In Vivo Chronic Wounds in Diabetic Foot Ulcers”
Place: Gustav Wieds Vej 10C, 8000 Aarhus C, Building 3130, Room 303.
Chronic wounds have become a global health problem. Chronic wounds are often infected with polymicrobial biofilms that hinders the normal healing of wounds. Consequently, chronic wounds remain in the inflammatory phase of healing. In vitro studies of chronic wounds often utilizes simple, monocultural models that exhibit unrealistic fast eradication of biofilms, once treated with antimicrobials. Given that these results are not observed in the clinic, there has become a need for more complex in vitro models comprised of multiple microbes. During my thesis, i aim to establish a polymicrobial, inter-kingdom biofilm model comprised of Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans.
Master Student
Lecture by: Alice Le Friec
Title: ”Cellularized biomaterials for neural tissue engineering”
Place: Gustav Wieds Vej 10C, 8000 Aarhus C, Building 3130, Room 303.
I will first discuss cell and biomaterial co-transplantation for regenerative medicine in the Central Nervous System. I will then introduce my latest research, which aims to design a cryopreservable cellularized scaffold for neural tissue repair.
Lecture by: Anne-Sofie Ravn Ballegaard
Title: ”Food allergy sensitization – knowledge from animal studies”
Place: Gustav Wieds Vej 10C, 8000 Aarhus C, Building 3130, Room 303.
The presentation will give an overview of food allergy and different routes of sensitization. This will include results from animal studies with a focus on intestinal permeability and immune responses.
Lecture by: Simon Sutter Rolighed
Title: ”Enriching synaptosomes for imaging”
Place: Gustav Wieds Vej 10C, 8000 Aarhus C, Building 3130, Room 303.
Synaptosomes are isolated synaptic terminals from neurons which are obtained by homogenization of brain tissue followed by fractionation using Percoll density gradient centrifugation. We have found that these samples contain a variety of vesicular structures making the search and identification of synaptosomes challenging and time-consuming task. I’ll discuss our efforts to selective enrich the sample for synaptosomes.
Lecture by: Naija From Munk-Pedersen
Title: “Development of new mri protocol for knee osteoarthritis”
Place: Gustav Wieds Vej 10C, 8000 Aarhus C, Building 3130, Room 303.
Lecture by: Nele Van Dessel, CEO from Ernest Pharmaceuticals (USA)
Title: "The use of Salmonella bacteria to treat cancer”
Place: Zoom, https://aarhusuniversity.zoom.us/j/62375855091
The microbial biotechnology course will host an online guest lecture on the use of Salmonella bacteria to treat cancer.
The guest speaker is Nele Van Dessel, CEO from Ernest Pharmaceuticals (USA), a small startup company, trying to bring this new and intriguing microbial biotechnology to the market.
