The ability to precisely control intracellular signaling in living tissue opens unprecedented opportunities for therapeutic intervention. Calcium is a ubiquitous intracellular messenger that mediates a wide variety of fundamental cellular processes of proliferation, differentiation, and programmed cell death. Precise modulation of calcium-dependent processes holds enormous promise for restoring physiological function. However, current technologies remain constrained by limited cellular specificity (neural prosthesis) or dependence on genetic modification (optogenetics). We aim to develop wireless biomodulation modalities facilitated by external remote fields, such as those generated by magnetic, optical, and acoustic stimuli, thanks to their precision and non‐invasive characteristics.