Aarhus Universitets segl

Multiscale Microbial Engineering

Biotechnology has the potential to make valuable contributions to face the grand challenges of global health, environment, and sustainable production. However, this requires efficient and robust cell factories. Cells contain multiple functions for ensuring survival in nature, under conditions that are different from industrial bioprocesses. Therefore, cellular resource allocation can reduce the productivity of the cell factory. The research group of Multiscale Microbial Engineering develops biological schemes to improve the performance of the cell factories under process-related stresses. Our approach includes the design of genetic circuits for controlling product formation, flux distribution and plasmids replication, as well as modification of the metabolic pathways. This is connected with the development of innovative culture schemes that can be applied in small-scale and industrial-scale systems.