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Department of Biological and Chemical Engineering

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Irla, M., Brito, L. F., Langlo, J., Wohlers, C., Benninghaus, L., Heid, C., Wendisch, V. F., Schmid, J. & Brautaset, T. (2026). Development of a markerless tool for targeted chromosome modification in the thermophilic and methylotrophic bacterium Bacillus methanolicus. Microbial Cell Factories, 25(1), Article 10. https://doi.org/10.1186/s12934-025-02880-0

Khider, M. L. K., Irla, M., López, M. G., Gispert, A., Konjetzko, T., Meliawati, M., Schmid, J., Brautaset, T. & Brito, L. F. (2026). CRISPR-Cas9-driven genome editing in Bacillus methanolicus MGA3. Frontiers in Microbiology, 16, Article 1728984. https://doi.org/10.3389/fmicb.2025.1728984

Brito, L. F., Luciano, D., Irla, M., Virant, D., Courtade, G. & Brautaset, T. (2025). Identification of MscS as a Key L-Glutamate Exporter in Bacillus methanolicus. Microbial Biotechnology, 18(10), Article e70252. https://doi.org/10.1111/1751-7915.70252

Brito, L. F., Friis, M. K., Zhu, H., Brautaset, T., Wendisch, V. F. & Irla, M. K. (2025). Tools and Strategies for Engineering Bacillus methanolicus: A Versatile Thermophilic Platform for Sustainable Bioproduction from Methanol and Alternative Feedstocks. Synthetic Biology and Engineering, 3(4). https://doi.org/10.70322/sbe.2025.10016

Huertas-Díaz, L., Vestergaard, L. G., Marietou, A., Irla, M., Behr, J., Somoza, M. M., Feilberg, A. & Schwab, C. (2025). Insights into the utilisation of 1,2-propanediol and interactions with the cell envelope of Clostridium perfringens. Gut Pathogens, 17(1), Article 23. https://doi.org/10.1186/s13099-025-00689-1

Irla, M., Nærdal, I., Virant, D., Brautaset, T., Busche, T., Goranovič, D., Haupka, C., Heux, S., Kosec, G., Rückert-Reed, C., Wendisch, V. F., Brito, L. F. & Vicente, C. M. (2025). Systems-level analysis provides insights on methanol-based production of L-glutamate and its decarboxylation product γ-aminobutyric acid by Bacillus methanolicus. Metabolic Engineering, 91, 389-404. https://doi.org/10.1016/j.ymben.2025.06.002

Lara, A. R., Andersen, M. B., Madsen, A. A. V., Fønss, K. G., Irla, M., Taymaz-Nikerel, H., Martínez, L. M., Dicke, M. D., Mann, M., Magnus, J. B. & Gosset, G. (2025). Biomanufacturing Potential of Streamlined Cells. Biotechnology and Bioengineering, 122(12), 3309-3318. https://doi.org/10.1002/bit.70070

Klein, V. J., Troøyen, S. H., Brito, L. F., Courtade, G., Brautaset, T. & Irla, M. K. (2024). Identification and characterization of a novel formaldehyde dehydrogenase in Bacillus subtilis. Applied and Environmental Microbiology, 90(11). https://doi.org/10.1128/aem.02181-23

Klein, V. J., Brito, L. F., Perez-Garcia, F., Brautaset, T. & Irla, M. (2023). Metabolic engineering of thermophilic Bacillus methanolicus for riboflavin overproduction from methanol. Microbial Biotechnology, 16(5), 1011-1026. https://doi.org/10.1111/1751-7915.14239

Irla, M. & Wendisch, V. F. (2022). Efficient cell factories for the production of N-methylated amino acids and for methanol-based amino acid production. Microbial Biotechnology, 15(8), 2145-2159. https://doi.org/10.1111/1751-7915.14067

Klein, V. J., Irla, M., López, M. G., Brautaset, T. & Brito, L. F. (2022). Unravelling Formaldehyde Metabolism in Bacteria: Road towards Synthetic Methylotrophy. Microorganisms, 10(2), Article 220. https://doi.org/10.3390/microorganisms10020220

Pérez-García, F., Brito, L. F., Irla, M., Jorge, J. M. P. & Sgobba, E. (2022). Editorial: Promising and sustainable microbial feedstocks for biotechnological processes. Frontiers in Microbiology, 13, Article 973723. https://doi.org/10.3389/fmicb.2022.973723

Brito, L. F., Irla, M., Nærdal, I., Le, S. B., Delépine, B., Heux, S. & Brautaset, T. (2021). Evaluation of Heterologous Biosynthetic Pathways for Methanol-Based 5-Aminovalerate Production by Thermophilic Bacillus methanolicus. Frontiers in Bioengineering and Biotechnology, 9, Article 686319. https://doi.org/10.3389/fbioe.2021.686319

Gruenberg, M., Irla, M., Myllek, S. & Draths, K. (2021). Characterization of two 3-deoxy-D-Arabino-Heptulosonate 7-phosphate synthases from Bacillus methanolicus. Protein Expression and Purification, 188, Article 105972. https://doi.org/10.1016/j.pep.2021.105972

Irla, M., Hakvåg, S. & Brautaset, T. (2021). Developing a riboswitch-mediated regulatory system for metabolic flux control in thermophilic bacillus methanolicus. International Journal of Molecular Sciences , 22(9), Article 4686. https://doi.org/10.3390/ijms22094686

Khider, M. L. K., Brautaset, T. & Irla, M. (2021). Methane monooxygenases: central enzymes in methanotrophy with promising biotechnological applications. World Journal of Microbiology and Biotechnology, 37(4), Article 72. https://doi.org/10.1007/s11274-021-03038-x

Drejer, E. B., Chan, D. T. C., Haupka, C., Wendisch, V. F., Brautaset, T. & Irla, M. (2020). Methanol-based acetoin production by genetically engineered: Bacillus methanolicus. Green Chemistry, 22(3), 788-802. https://doi.org/10.1039/c9gc03950c

Haupka, C., Delépine, B., Irla, M., Heux, S. & Wendisch, V. F. (2020). Flux enforcement for fermentative production of 5-aminovalerate and glutarate by corynebacterium glutamicum. Catalysts, 10(9), 1-15. Article 1065. https://doi.org/10.3390/catal10091065

Irla, M., Drejer, E. B., Brautaset, T. & Hakvåg, S. (2020). Establishment of a functional system for recombinant production of secreted proteins at 50 °c in the thermophilic Bacillus methanolicus. Microbial Cell Factories, 19(1), Article 151. https://doi.org/10.1186/s12934-020-01409-x

Gawin, A., Peebo, K., Hans, S., Ertesvåg, H., Irla, M., Neubauer, P. & Brautaset, T. (2019). Construction and characterization of broad-host-range reporter plasmid suitable for on-line analysis of bacterial host responses related to recombinant protein production. Microbial Cell Factories, 18(1), Article 80. https://doi.org/10.1186/s12934-019-1128-7

López, M. G., Irla, M., Brito, L. F. & Wendisch, V. F. (2019). Characterization of D-arabitol as newly discovered carbon source of Bacillus methanolicus. Frontiers in Microbiology, 10(JULY), Article 1725. https://doi.org/10.3389/fmicb.2019.01725

Drejer, E. B., Hakvåg, S., Irla, M. & Brautaset, T. (2018). Genetic tools and techniques for recombinant expression in thermophilic bacillaceae. Microorganisms, 6(2), Article 42. https://doi.org/10.3390/microorganisms6020042

Brito, L. F., Irla, M., Kalinowski, J. & Wendisch, V. F. (2017). Detailed transcriptome analysis of the plant growth promoting Paenibacillus riograndensis SBR5 by using RNA-seq technology. BMC Genomics, 18(1), Article 846. https://doi.org/10.1186/s12864-017-4235-z

Brito, L. F., Irla, M., Walter, T. & Wendisch, V. F. (2017). Magnesium aminoclay-based transformation of Paenibacillus riograndensis and Paenibacillus polymyxa and development of tools for gene expression. Applied Microbiology and Biotechnology, 101(2), 735-747. https://doi.org/10.1007/s00253-016-7999-1

Irla, M., Nærdal, I., Brautaset, T. & Wendisch, V. F. (2017). Methanol-based γ-aminobutyric acid (GABA) production by genetically engineered Bacillus methanolicus strains. Industrial Crops and Products, 106, 12-20. https://doi.org/10.1016/j.indcrop.2016.11.050

Nærdal, I., Netzer, R., Irla, M., Krog, A., Heggeset, T. M. B., Wendisch, V. F. & Brautaset, T. (2017). L-lysine production by Bacillus methanolicus: Genome-based mutational analysis and L-lysine secretion engineering. Journal of Biotechnology, 244, 25-33. https://doi.org/10.1016/j.jbiotec.2017.02.001

Irla, M., Heggeset, T. M. B., Nærdal, I., Paul, L., Haugen, T., Le, S. B., Brautaset, T. & Wendisch, V. F. (2016). Genome-based genetic tool development for Bacillus methanolicus: Theta-and rolling circle-replicating plasmids for inducible gene expression and application to methanol-based cadaverine production. Frontiers in Microbiology, 7(SEP), Article 1481. https://doi.org/10.3389/fmicb.2016.01481

Irla, M., Neshat, A., Brautaset, T., Rückert, C., Kalinowski, J. & Wendisch, V. F. (2015). Transcriptome analysis of thermophilic methylotrophic Bacillus methanolicus MGA3 using RNA-sequencing provides detailed insights into its previously uncharted transcriptional landscape. BMC Genomics, 16(1), Article 73. https://doi.org/10.1186/s12864-015-1239-4

Irla, M., Neshat, A., Winkler, A., Albersmeier, A., Heggeset, T. M. B., Brautaset, T., Kalinowski, J., Wendisch, V. F. & Rückert, C. (2014). Complete genome sequence of Bacillus methanolicus MGA3, a thermotolerant amino acid producing methylotroph. Journal of Biotechnology, 188, 110-111. https://doi.org/10.1016/j.jbiotec.2014.08.013

Wikiera, A., Irla, M. & Mika, M. (2014). Prozdrowotne wlas̈ciwos̈ci pektyn. Postepy Higieny i Medycyny Doswiadczalnej, 68, 590-596. https://doi.org/10.5604/17322693.1102342

Pociecha, E., Płazek, A., Janowiak, F., Dubert, F., Kolasińska, I. & Irla, M. (2013). Factors contributing to enhanced pink snow mould resistance of winter rye (Secale cereale L.) - Pivotal role of crowns. Physiological and Molecular Plant Pathology, 81, 54-63. https://doi.org/10.1016/j.pmpp.2012.10.007

Revised 02.01.2026

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Marta Katarzyna Irla