Publications by Molecular and Cellular Biotechnology

Are you looking for publications by Molecular and Cellular Biotechnology? On this page you can find all the publications made by the Molecular and Cellular Biotechnology - Department of Biological & Chemical Engineering, Aarhus University.

Below you can find a list of all the publications, their publishing date, their author(s), and titles. The list can be sorted by date, author, and title:

List of Publications

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Baur, S. T., Schulz, S., McCluskey, J. B., Velázquez Gómez, J. A., Angenent, L. T. & Molitor, B. (2025). Deletion of aldehyde:ferredoxin oxidoreductase-encoding genes in Clostridium ljungdahlii results in changes in product spectrum with various carbon sources. Bioresource Technology, 431, Artikel 132596. https://doi.org/10.1016/j.biortech.2025.132596

Wijesooriya, M. M., Vithanage, M. & Wijesekara, H. (2025). Underestimated Threats: Personal Care Products (PCPs) in Marine and Coastal Environments. I M. Vithanage, S. M. Samarasekara, B. D. James & C. M. Reddy (red.), Coastal and Marine Pollution: Source to Sink, Mitigation and Management (s. 225-248). Wiley. https://doi.org/10.1002/9781394237029.ch12

Sieborg, M. U. & Kofoed, M. V. W. (2025). Gamle processer, nye muligheder: Nyt kemisk-biologisk koncept til CO2-fangst og omdannelse. Dansk Kemi, 106(2), 12-14. Artikel 106. https://ipaper.ipapercms.dk/TechMedia/DanskKemi/2025/2/?page=12

Ouyang, Y., Zhang, C., Wang, J., Guo, Z., Wang, Z. & Dong, M. (2025). Gate-Tunable Dual-Mode Optoelectronic Device for Self-Powered Photodetector and Optoelectronic Synapse. Advanced Science, 12(17), Artikel 2416259. https://doi.org/10.1002/advs.202416259

Tvilum, M., Lutz, C. M., Knap, M. M., Hoffmann, L., Khalil, A. A., Holt, M. I., Kandi, M., Schmidt, H. H., Appelt, A. L., Alber, M. & Møller, D. S. (2023). Different benefits of adaptive radiotherapy for different histologies of NSCLC. Acta Oncologica, 62(11), 1426-1432. https://doi.org/10.1080/0284186X.2023.2260944

Lærke, H. N., Jensen, S. K., Andrade, T. A., Ambye-Jensen, M., Jørgensen, E. T. & Stødkilde, L. (2025). Towards efficient grass-clover biorefining: Influence of harvesting methods and delayed processing. Animal Feed Science and Technology, 324, Artikel 116336. https://doi.org/10.1016/j.anifeedsci.2025.116336

Huertas-Díaz, L., Vestergaard, L. G., Marietou, A., Irla, M., Behr, J., Somoza, M. M., Feilberg, A. & Schwab, C. (2025). Insights into the utilisation of 1,2-propanediol and interactions with the cell envelope of Clostridium perfringens. Gut Pathogens, 17(1), Artikel 23. https://doi.org/10.1186/s13099-025-00689-1

Ma, Y., Bittner, J. P., Vernet, G., Zhang, N. & Kara, S. (2025). Linkers in Action: Exploring Fusion Enzymes for Oxyfunctionlizations in Non-Conventional Media Through Experiments and Simulations. ChemCatChem, 17(9), Artikel e202401893. https://doi.org/10.1002/cctc.202401893

Milić, M., Vernet, G., Le, H. Y., Zhang, N., Byström, E., Domínguez de María, P. & Kara, S. (2025). Assessing the Industrial Edge of the Lipase-Mediated Oxidation of 2,5-Diformylfuran to 2,5-Furandicarboxylic Acid: Rotating Bed Reactors, an “Acyl-Donor-Free” Oxidation Concept, and Environmental Aspects. Organic Process Research and Development, 29(4), 1058-1066. https://doi.org/10.1021/acs.oprd.4c00474

Zhang, N., Lahmann, V., Bittner, J. P., Domínguez de María, P., Jakobtorweihen, S., Smirnova, I. & Kara, S. (2025). Redox Biocatalysis in Lidocaine-Based Hydrophobic Deep Eutectic Solvents: Non-Conventional Media Outperform Aqueous Conditions. ChemSusChem, 18(6), Artikel e202402075. https://doi.org/10.1002/cssc.202402075

Xie, J., Veigel, M., Schmidt, H. & Gänzle, M. (2025). Selection of Bacillus spp. as fermentation cultures for production of plant-based cheese analogues. International Journal of Food Microbiology, 435, Artikel 111178. https://doi.org/10.1016/j.ijfoodmicro.2025.111178

Lülf, R. H., Vogel, R. F. & Ehrmann, M. A. (2021). Microbiota dynamics and volatile compounds in lupine based Moromi fermented at different salt concentrations. International Journal of Food Microbiology, 354, Artikel 109316. https://doi.org/10.1016/j.ijfoodmicro.2021.109316

Link, T., Lülf, R. H., Parr, M., Hilgarth, M. & Ehrmann, M. A. (2022). Genome Sequence of the Diploid Yeast Debaryomyces hansenii TMW 3.1188. Microbiology Resource Announcements, 11(11). https://doi.org/10.1128/mra.00649-22

Lülf, R. H., Hilgarth, M. & Ehrmann, M. A. (2022). Chromohalobacter moromii sp. nov., a moderately halophilic bacterium isolated from lupine-based moromi fermentation. Systematic and Applied Microbiology, 45(4), Artikel 126324. https://doi.org/10.1016/j.syapm.2022.126324

Lülf, R. H., Selg-Mann, K., Hoffmann, T., Zheng, T., Schirmer, M. & Ehrmann, M. A. (2023). Carbohydrate Sources Influence the Microbiota and Flavour Profile of a Lupine-Based Moromi Fermentation. Foods, 12(1), Artikel 197. https://doi.org/10.3390/foods12010197

Ma, Y., Vernet, G., Zhang, N. & Kara, S. (2025). Exploring DES-Water Mixtures for Improved ADH-CHMO Fusion Enzyme Performance in Linear Cascades. ChemCatChem, 17(5), Artikel e202401792. https://doi.org/10.1002/cctc.202401792

Gemeinhardt, K., Jeon, B. S., Ntihuga, J. N., Wang, H., Schlaiß, C., Lucas, T. N., Bessarab, I., Nalpas, N., Zhou, N., Usack, J. G., Huson, D. H., Williams, R. B. H., Maček, B., Aristilde, L. & Angenent, L. T. (2025). Toward industrial C8 production: oxygen intrusion drives renewable n-caprylate production from ethanol and acetate via intermediate metabolite production. Green Chemistry, 27(11), 2931-2949. https://doi.org/10.1039/d5gc00411j

Gonzalez-Serrano, D. J., Benmebarek, I. E., Hadidi, M., Bechtner, J. D., Martinez, M. M., Cabañas, B. & Moreno, A. (2025). Optimization of microwave-assisted hydrothermal extraction of homogalacturonan-rich, low methoxyl pectin from discarded garlic peels: Comparative macromolecular and functional analysis with conventional extraction. Food Hydrocolloids, 166, Artikel 111324. https://doi.org/10.1016/j.foodhyd.2025.111324

Temovska, M., Hegner, R., Ortiz-Ardila, A. E., Usack, J. G. & Angenent, L. T. (2025). Lactate production from lactose-rich wastewater: A comparative study on reactor configurations to maximize conversion rates and efficiencies. Water Research, 278, Artikel 123365. https://doi.org/10.1016/j.watres.2025.123365

Lara, A. R. & Gosset, G. (2019). Preface. I Minimal Cells: Design, Construction, Biotechnological Applications (s. v-vi). Springer International Publishing.

Pablos, T. E., Sigala, J. C., Le Borgne, S. & Lara, A. R. (2014). Aerobic expression of Vitreoscilla hemoglobin efficiently reduces overflow metabolism in Escherichia coli. Biotechnology Journal, 9(6), 791-799. https://doi.org/10.1002/biot.201300388

de la Cruz, M., Ramírez, E. A., Sigala, J. C., Utrilla, J. & Lara, A. R. (2020). Plasmid DNA production in proteome-reduced Escherichia coli. Microorganisms, 8(9), 1-8. Artikel 1444. https://doi.org/10.3390/microorganisms8091444

Chávez-Béjar, M. I., Lara, A. R., López, H., Hernández-Chávez, G., Martinez, A., Ramírez, O. T., Bolívar, F. & Gosset, G. (2008). Metabolic engineering of Escherichia coli for L-tyrosine production by expression of genes coding for the chorismate mutase domain of the native chorismate mutase-prephenate dehydratase and a cyclohexadienyl dehydrogenase from Zymomonas mobilis. Applied and Environmental Microbiology, 74(10), 3284-3290. https://doi.org/10.1128/AEM.02456-07

Lara, A. R. & Gosset, G. (2019). Minimal cells: Design, construction, biotechnological applications. Springer International Publishing. https://doi.org/10.1007/978-3-030-31897-0

Borja, G. M., Meza Mora, E., Barrón, B., Gosset, G., Ramírez, O. T. & Lara, A. R. (2012). Engineering Escherichia coli to increase plasmid DNA production in high cell-density cultivations in batch mode. Microbial Cell Factories, 11, Artikel 132. https://doi.org/10.1186/1475-2859-11-132

Taymaz-Nikerel, H. & Lara, A. R. (2016). Editorial: Quantitative systems biology for engineering organisms and pathways. Frontiers in Bioengineering and Biotechnology, 4(MAR), Artikel 22. https://doi.org/10.3389/fbioe.2016.00022

Jaén, K. E., Velazquez, D., Sigala, J. C. & Lara, A. R. (2021). Enhancing microaerobic plasmid DNA production by chromosomal expression of Vitreoscilla hemoglobin in E. coli. Biochemical Engineering Journal, 166, Artikel 107862. https://doi.org/10.1016/j.bej.2020.107862

Lara, A. R., Caspeta, L., Gosset, G., Bolívar, F. & Ramírez, O. T. (2008). Utility of an Escherichia coli strain engineered in the substrate uptake system for improved culture performance at high glucose and cell concentrations: An alternative to fed-batch cultures. Biotechnology and Bioengineering, 99(4), 893-901. https://doi.org/10.1002/bit.21664

Fuentes, L. G., Lara, A. R., Martínez, L. M., Ramírez, O. T., Martínez, A., Bolívar, F. & Gosset, G. (2013). Modification of glucose import capacity in Escherichia coli: Physiologic consequences and utility for improving DNA vaccine production. Microbial Cell Factories, 12(1), Artikel 42. https://doi.org/10.1186/1475-2859-12-42

Jaén, K. E., Lara, A. R. & Ramírez, O. T. (2013). Effect of heating rate on pDNA production by E. coli. Biochemical Engineering Journal, 79, 230-238. https://doi.org/10.1016/j.bej.2013.08.006

Jaén, K. E., Velazquez, D., Delvigne, F., Sigala, J. C. & Lara, A. R. (2019). Engineering E. coli for improved microaerobic pDNA production. Bioprocess and Biosystems Engineering, 42(9), 1457-1466. https://doi.org/10.1007/s00449-019-02142-5

Caspeta, L., Lara, A. R., Pérez, N. O., Flores, N., Bolívar, F. & Ramírez, O. T. (2013). Enhancing thermo-induced recombinant protein production in Escherichia coli by temperature oscillations and post-induction nutrient feeding strategies. Journal of Biotechnology, 167(1), 47-55. https://doi.org/10.1016/j.jbiotec.2013.06.001

Pablos, T. E., Soto, R., Mora, E. M., Le Borgne, S., Ramírez, O. T., Gosset, G. & Lara, A. R. (2012). Enhanced production of plasmid DNA by engineered Escherichia coli strains. Journal of Biotechnology, 158(4), 211-214. https://doi.org/10.1016/j.jbiotec.2011.04.015

Lara, A. R., Jaén, K. E., Sigala, J. C., Regestein, L. & Büchs, J. (2017). Evaluation of microbial globin promoters for oxygen-limited processes using Escherichia coli. Journal of Biological Engineering, 11(1), Artikel 39. https://doi.org/10.1186/s13036-017-0082-3

Lara, A. R., Knabben, I., Regestein, L., Sassi, J., Caspeta, L., Ramírez, O. T. & Büchs, J. (2011). Comparison of oxygen enriched air vs. pressure cultivations to increase oxygen transfer and to scale-up plasmid DNA production fermentations. Engineering in Life Sciences, 11(4), 382-386. https://doi.org/10.1002/elsc.201000104

Lara, A. R., Leal, L., Flores, N., Gosset, G., Bolívar, F. & Ramírez, O. T. (2006). Transcriptional and metabolic response of recombinant Escherichia coli to spatial dissolved oxygen tension gradients simulated in a scale-down system. Biotechnology and Bioengineering, 93(2), 372-385. https://doi.org/10.1002/bit.20704

Knabben, I., Regestein, L., Marquering, F., Steinbusch, S., Lara, A. R. & Büchs, J. (2010). High cell-density processes in batch mode of a genetically engineered Escherichia coli strain with minimized overflow metabolism using a pressurized bioreactor. Journal of Biotechnology, 150(1), 73-79. https://doi.org/10.1016/j.jbiotec.2010.07.006

Galindo, J., Barrón, B. L. & Lara, A. R. (2016). Improved production of large plasmid DNA by enzyme-controlled glucose release. Annals of Microbiology, 66(3), 1337-1342. https://doi.org/10.1007/s13213-016-1218-2

Lara, A. R., Palomares, L. A. & Ramírez, O. T. (2016). Scale-down: Simulating large-scale cultures in the laboratory. I Industrial Biotechnology: Products and Processes (s. 55-79). Wiley-VCH Verlag GmbH. https://doi.org/10.1002/9783527807833

Pablos, T. E., Olivares, R., Sigala, J. C., Ramírez, O. T. & Lara, A. R. (2016). Toward efficient microaerobic processes using engineered Escherichia coli W3110 strains. Engineering in Life Sciences, 16(7), 588-597. https://doi.org/10.1002/elsc.201500129

Gálvez, R. M., Pablos, T. E., Sigala, J. C. & Lara, A. R. (2014). Co-utilization of glucose and xylose increases growth rate without affecting plasmid dna yield of engineered E. coli. Revista Mexicana de Ingeniera Quimica, 13(2), 387-391.

Freudenau, I., Lutter, P., Baier, R., Schleef, M., Bednarz, H., Lara, A. R. & Niehaus, K. (2015). ColE1-plasmid production in Escherichia coli: Mathematical simulation and experimental validation. Frontiers in Bioengineering and Biotechnology, 3(SEP), Artikel 127. https://doi.org/10.3389/fbioe.2015.00127

Baert, J., Delepierre, A., Telek, S., Fickers, P., Toye, D., Delamotte, A., Lara, A. R., Jaén, K. E., Gosset, G., Jensen, P. R. & Delvigne, F. (2016). Microbial population heterogeneity versus bioreactor heterogeneity: Evaluation of Redox Sensor Green as an exogenous metabolic biosensor. Engineering in Life Sciences, 16(7), 643-651. https://doi.org/10.1002/elsc.201500149

Sigala, J. C., Suárez, B. P., Lara, A. R., Borgne, S. L., Bustos, P., Santamaría, R. I., González, V. & Martinez, A. (2017). Genomic and physiological characterization of a laboratory-isolated Acinetobacter schindleri ACE strain that quickly and efficiently catabolizes acetate. Microbiology (United Kingdom), 163(7), 1052-1064. https://doi.org/10.1099/mic.0.000488

Lara, A. R. & Ramírez, O. T. (2012). Plasmid DNA production for therapeutic applications. I A. Lorence (red.), Recombinant Gene Expression: Reviews and Protocols, Third Edition (s. 271-303) https://doi.org/10.1007/978-1-61779-433-9_14

De Anda, R., Lara, A. R., Hernández, V., Hernández-Montalvo, V., Gosset, G., Bolívar, F. & Ramírez, O. T. (2006). Replacement of the glucose phosphotransferase transport system by galactose permease reduces acetate accumulation and improves process performance of Escherichia coli for recombinant protein production without impairment of growth rate. Metabolic Engineering, 8(3), 281-290. https://doi.org/10.1016/j.ymben.2006.01.002

Arteaga, J. E., Cerros, K., Rivera-Becerril, E., Lara, A. R., Le Borgne, S. & Sigala, J. C. (2021). Furfural biotransformation in Acinetobacter baylyi ADP1 and Acinetobacter schindleri ACE. Biotechnology Letters , 43(5), 1043-1050. https://doi.org/10.1007/s10529-021-03094-1

Beltran, N. E., Reyes, A. & Lara, A. R. (2014). Cardiac tissue engineering as an alternative to current therapies: Economical and technical challenges. Experimental and Clinical Cardiology, 20(8), 3375-3388.

Wunderlich, M., Taymaz-Nikerel, H., Gosset, G., Ramírez, O. T. & Lara, A. R. (2014). Effect of growth rate on plasmid DNA production and metabolic performance ofengineered Escherichia coli strains. Journal of Bioscience and Bioengineering, 117(3), 336-342. https://doi.org/10.1016/j.jbiosc.2013.08.007

Mairhofer, J. & Lara, A. R. (2014). Advances in host and vector development for the production of plasmid DNA vaccines. Methods in Molecular Biology, 1139, 505-541. https://doi.org/10.1007/978-1-4939-0345-0_38

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