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Institut for Bio- og Kemiteknologi

Publications

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Spillner, E., Blank, S. & Jakob, T. (2014). Hymenoptera allergens: from venom to ”venome”. Frontiers in Immunology, 5(77). https://doi.org/10.3389/fimmu.2014.00077

Cifuentes, L., Vosseler, S., Blank, S., Seismann, H., Grunwald, T., Darsow, U., Bredehorst, R., Mempel, M., Spillner, E., Ring, J. & Ollert, M. (2014). Identification of hymenoptera venom-allergic patients with negative specific IgE to venom extract by using recombinant allergens. Journal of Allergy and Clinical Immunology, 133(3), 909-910.

Rafei-Shamsabadi, D., Müller, S., Pfützner, W., Spillner, E., Rueff, F. & Jakob, T. (2014). Recombinant allergens rarely allow identification of Hymenoptera venom-allergic patients with negative specific IgE to whole venom preparations. Journal of Allergy and Clinical Immunology, 134(2), 493-494. https://doi.org/10.1016/j.jaci.2014.05.035

Bredehorst, R., Grunwald, T., Ollert, M. W., Schmidt-Weber, C. & Spillner, E. (2014). Selective local inhibition of TNFR1-mediated functions at the site of antigen/allergen presentation.

Bredehorst, R., Grunwald, T., Ollert, M., Schmidt-Weber, C. & Spillner, E. (2013). Controlled activation of complement components for use as endogenous adjuvant.

Kötzler, M. P., Blank, S., Bantleon, F. I., Wienke, M., Spillner, E. & Meyer, B. (2013). Donor assists acceptor binding and catalysis of human α1,6-fucosyltransferase. A C S Chemical Biology, 8(8), 1830-40. https://doi.org/10.1021/cb400140u

Van Vaerenbergh, M., Cardoen, D., M. Formesyn, E., Brunain, M., Van Driessche, G., Blank, S., Spillner, E., Verleyen, P., Wenseleers, T., Schoofs, L., Devreese, B. & C. de Graaf, D. (2013). Extending the honeybee venome with the antimicrobial peptide apidaecin and a protein resembling wasp antigen 5. Insect Molecular Biology, 22(2), 199-210.

Bredehorst, R., Grunwald, T., Ollert, M., Schmidt-Weber, C. & Spillner, E. (2013). Modulation of effector T cell responses by local depletion of complement component C3.

Blank, S., Neu, C., Hasche, D., Bantleon, F. I., Jakob, T. & Spillner, E. (2013). Polistes species venom is devoid of carbohydrate-based cross-reactivity and allows interference-free diagnostics. The Journal of allergy and clinical immunology, 131(4), 1239-42. https://doi.org/10.1016/j.jaci.2012.10.047

Blank, S., Seismann, H., McIntyre, M., Ollert, M., Wolf, S., Bantleon, F. I. & Spillner, E. (2013). Vitellogenins Are New High Molecular Weight Components and Allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris Venom. P L o S One, 8(4). https://doi.org/10.1371/journal.pone.0062009

Hecker, J., Diethers, A., Schulz, D., Sabri, A., Plum, M., Michel, Y., Mempel, M., Ollert, M., Jakob, T., Blank, S., Braren, I. & Spillner, E. (2012). An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE. Allergy: European Journal of Allergy and Clinical Immunology, 67(12), 1530-1537. https://doi.org/10.1111/all.12045

Wehr, C., Müller, F., Schüler, J., Tomann, T., Nitschke, C., Seismann, H., Spillner, E., Klingner, K., Schneider-Merck, T., Binder, M., Fiebig, H.-H., Mertelsmann, R. & Trepel, M. (2012). Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model. International Journal of Cancer, 131(2), E10-20. https://doi.org/10.1002/ijc.26464

Spillner, E., Greunke, K., Seismann, H., Blank, S., Braren, I. & du Plessis, D. (2012). Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy. Biologicals, 40(5), 313-322. https://doi.org/10.1016/j.biologicals.2012.05.003

Jakob, T., Köhler, J., Blank, S., Spillner, E., Magnusson, U., Lidholm, J. & Huss-Marp, J. (2012). Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant-negative patients with bee venom allergy. Journal of Allergy and Clinical Immunology, 130(1), 276-278. https://doi.org/10.1016/j.jaci.2012.03.048

Kötzler, M. P., Blank, S., Bantleon, F. I., Spillner, E. & Meyer, B. (2012). Donor substrate binding and enzymatic mechanism of human core α1,6-fucosyltransferase (FUT8). B B A - General Subjects, 1820(12), 1915-1925. https://doi.org/10.1016/j.bbagen.2012.08.018

Sidiropoulos, P., Miehe, M., Bock, T., Tinelli, E., Oertli, C., Kuner, R., Meijer, D., Wollscheid, B., Niemann, A. & Suter, U. (2012). Dynamin 2 mutations in Charcot–Marie–Tooth neuropathy highlight the importance of clathrin-mediated endocytosis in myelination. Brain, 135(5), 1395-1411. https://doi.org/10.1093/brain/aws061

Kötzler, M. P., Blank, S., Behnken, H. N., Alpers, D., Bantleon, F. I., Spillner, E. & Meyer, B. (2012). Formation of the immunogenic α1,3-fucose epitope: elucidation of substrate specificity and of enzyme mechanism of core fucosyltransferase A. Insect Biochemistry and Molecular Biology, 42(2), 116-25. https://doi.org/10.1016/j.ibmb.2011.11.004

Spillner, E., Blank, S. & Jakob, T. (2012). Potenzial, Fallstricke und aktueller Status der molekularen Diagnostik am Beispiel der Insektengiftallergie. Allergo Journal, 21(4), 249-256. https://doi.org/10.1007/s15007-012-0128-2

Spillner, E., Plum, M., Blank, S., Miehe, M., Singer, J. & Braren, I. (2012). Recombinant IgE antibody engineering to target EGFR. Cancer Immunology, Immunotherapy, 61(9), 1565-73. https://doi.org/10.1007/s00262-012-1287-4

Blank, S., Bantleon, F. I., Ollert, M., McIntyre, M. & Spillner, E. (2012). The major royal jelly proteins 8 and 9 (Api m 11) are glycosylated components of Apis mellifera venom with allergenic potential beyond carbohydrate-based reactivity. Clinical and Experimental Allergy, 42(6), 976-985. https://doi.org/10.1111/j.1365-2222.2012.03966.x

Michel, Y., Ginglinger, H., Blank, S., McIntyre, M., Ollert, M., Cifuentes, L. & Spillner, E. (2012). The putative serine protease inhibitor Api m 6 from Apis Mellifera venom: Recombinant and structural evaluation. Journal of Investigational Allergology and Clinical Immunology, 22(7), 476-484.

Blank, S., Seismann, H., Michel, Y., McIntyre, M., Cifuentes, L., Braren, I., Grunwald, T., Darsow, U., Ring, J., Bredehorst, R., Ollert, M. & Spillner, E. (2011). Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extracts. Allergy: European Journal of Allergy and Clinical Immunology, 66(10), 1322-1329. https://doi.org/10.1111/j.1398-9995.2011.02667.x

Plum, M., Michel, Y., Wallach, K., Raiber, T., Blank, S., Bantleon, F. I., Diethers, A., Greunke, K., Braren, I., Hackl, T., Meyer, B. & Spillner, E. (2011). Close-up of the alpha-1,3-Gal epitope as defined by a monoclonal chimeric IgE and human serum using saturation transfer difference (STD) NMR. Journal of Biological Chemistry, 286(50), 43103-11. https://doi.org/10.1074/jbc.M111.291823

Sturm, G. J., Bokanovic, D., Aberer, W., Hemmer, W., Hawranek, T., Lang, R., Ollert, M., Spillner, E. & Blank, S. (2011). Detection of IgE to recombinant Api m 1 and rVes v 5 is valuable but not sufficient to distinguish bee from wasp venom allergy. Journal of Allergy and Clinical Immunology, 128(1), 247-248. https://doi.org/10.1016/j.jaci.2011.02.021

Blank, S., Seismann, H., Plum, M., Greunke, K., Grunwald, T., Bredehorst, R., Ollert, M., Braren, I. & Spillner, E. (2011). Evaluation of different glycoforms of honeybee venom major allergen phospholipase A2 (Api m 1) produced in insect cells. Protein and Peptide Letters, 18(4), 415-422.

Hecker, J., Diethers, A., Seismann, H., Michel, Y., Plum, M., Bredehorst, R., Blank, S., Etzold, S., Braren, I. & Spillner, E. (2011). Generation and epitope analysis of human monoclonal antibody isotypes with specificity for the timothy grass major allergen Phl p 5a. Molecular Immunology, 48(9-10), 1236-1244. https://doi.org/10.1016/j.molimm.2011.03.005

Braren, I., Greunke, K., Grunwald, T., Pilette, C., Mempel, M., Bredehorst, R., Ring, J., Spillner, E. & Ollert, M. (2011). Quantitation of serum IgE by using chimeras of human IgE receptor and avian immunoglobulin domains. Analytical Biochemistry, 412(2), 134-140. https://doi.org/10.1016/j.ab.2010.12.013

Jakob, T., Blank, S., Spillner, E. & Ollert, M. (2011). Rekombinante Insektengift-Allergene: Ist das Bienen- oder doch das Wespengift schuld? Der Deutsche Dermatologe, 59, 759-761.

Hofmann, S. C., Pfender, N., Weckesser, S., Jakob, T., Blank, S., Spillner, E. & Huss-Marp, J. (2011). Reply. Journal of Allergy and Clinical Immunology, 128(1), 248. https://doi.org/10.1016/j.jaci.2011.02.020

Spillner, E., Laursen, N. S., Andersen, K. R., Sottrup-Jensen, L., Andersen, G. R. & Braren, I. (2011). Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. E M B O Journal, 30(3), 606-616. https://doi.org/10.1038/emboj.2010.341

Pereira, J. A., Baumann, R., Norrmén, C., Somandin, C., Miehe, M., Jacob, C., Lühmann, T., Hall-Bozic, H., Mantei, N., Meijer, D. & Suter, U. (2010). Dicer in Schwann cells is required for myelination and axonal integrity. Journal of Neuroscience, 19, 6763.

Seismann, H., Blank, S., Braren, I., Greunke, K., Cifuentes, L., Grunwald, T., Bredehorst, R., Ollert, M. & Spillner, E. (2010). Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation. Molecular immunology, 47(4), 799-808. https://doi.org/10.1016/j.molimm.2009.10.005

Blank, S., Seismann, H., Bockisch, B., Rühl, D., Bredehorst, R., Braren, I., Grunwald, T., Cifuentes, L., McIntyre, M., Ring, J., Ollert, M. W. & Spillner, E. (2010). Identification, recombinant expression, and characterization of the 100 kDa high molecular weight hymenoptera venom allergens Api m 5 and Ves v 3. Journal of Immunology, 184(9), 5403-5413. https://doi.org/10.4049/jimmunol.0803709

Seismann, H., Blank, S., Cifuentes, L., Braren, I., Bredehorst, R., Grunwald, T., Ollert, M. & Spillner, E. (2010). Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivity. Clinical and Molecular Allergy, 8. https://doi.org/10.1186/1476-7961-8-7

Binder, M., Léchenne, B., Ummanni, R., Balabanov, S., Trepel, M., Scharf, C., Trusch, M., Schlüter, H., Braren, I. & Spillner, E. (2010). Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells. P L o S One, 5(12), Artikel e15992. https://doi.org/10.1371/journal.pone.0015992

Spillner, E., Laursen, N. S., Christensen, J. B., Jensen, M., Fredslund, F., Sottrup-Jensen, L., Andersen, G. R., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Fraser, J. D., Wines, B. & Bjerre, M. (2010). Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus. Proceedings of the National Academy of Sciences (PNAS), 107(8), 3681-3686. https://doi.org/10.1073/pnas.0910565107

Braren, I., Bredehorst, R., Ollert, M., Grunwald, T., Spillner, E. & Ring, J. (2009). Antibody compositions specific for IgE, IgG4 and IgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy.

Deckers, S., Braren, I., Greunke, K., Meyer, N., Rühl, D., Bredehorst, R. & Spillner, E. (2009). Establishment of hapten-specific monoclonal avian IgY by conversion of antibody fragments obtained from combinatorial libraries. Biotechnology and Applied Biochemistry, 52(Pt 1), 79-87. https://doi.org/10.1042/BA20080032

Greunke, K., Braren, I., Alpers, I., Blank, S., Sodenkamp, J., Bredehorst, R. & Spillner, E. (2008). Recombinant IgY for improvement of immunoglobulin-based analytical applications. Clinical Biochemistry, 41(14-15), 1237-44. https://doi.org/10.1016/j.clinbiochem.2008.07.004

Bredehorst, R., Greunke, K., Grunwald, T. & Spillner, E. (2007). Bivalent IgY antibody constructs for diagnostic and therapeutic applications.

Braren, I., Greunke, K., Umland, O., Deckers, S., Bredehorst, R. & Spillner, E. (2007). Comparative expression of different antibody formats in mammalian cells and Pichia pastoris. Biotechnology and Applied Biochemistry, 47(4), 205-14. https://doi.org/10.1042/BA20060170

Braren, I., Blank, S., Seismann, H., Deckers, S., Ollert, M., Grunwald, T. & Spillner, E. (2007). Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries. Clinical Chemistry, 53(5), 837-44. https://doi.org/10.1373/clinchem.2006.078360

Sonnenberg-Riethmacher, E., Wüstefeld, T., Miehe, M., Trautwein, C. & Riethmacher, D. (2007). Maid (GCIP) is involved in cell cycle control of hepatocytes. Hepatology, 45(2), 404.

Bredehorst, R., Glökler, J., Grunwald, T., Matzas, M. & Spillner, E. (2007). Method for determining an unknown PNA [peptide nucleic acid] sequence and uses thereof.

Kölln, J., Braren, I., Bredehorst, R. & Spillner, E. (2007). Purification of native and recombinant cobra venom factor using thiophilic adsorption chromatography. Protein and Peptide Letters, 14(5), 475-80.

Greunke, K., Spillner, E., Braren, I., Seismann, H., Kainz, S., Hahn, U., Grunwald, T. & Bredehorst, R. (2006). Bivalent monoclonal IgY antibody formats by conversion of recombinant antibody fragments. Journal of Biotechnology, 124(2), 446-56. https://doi.org/10.1016/j.jbiotec.2005.12.032

Münster, J., Ziegelmüller, P., Spillner, E. & Bredehorst, R. (2006). High level expression of monomeric and dimeric human alpha1,3-fucosyltransferase V. Journal of Biotechnology, 121(4), 448-57. https://doi.org/10.1016/j.jbiotec.2005.08.015

Spillner, E., Kölln, J. & Bredehorst, R. (2006). Inactivation of complement by recombinant human C3 derivatives. I Current Topics in Complement (Bind 586, s. 347-60)

Grunwald, T., Bockisch, B., Spillner, E., Bredehorst, R., Ring, J. & Ollert, M. W. (2006). Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3). Journal of Allergy and Clinical Immunology, 117(4), 848-854. https://doi.org/10.1016/j.jaci.2005.12.1331

Kolln, J., Ren, H.-M., Da, R.-R., Zhang, Y., Spillner, E., Olek, M., Hermanowicz, N., Hilgenberg, L. G., Smith, M. A., van den Noort, S. & Qin, Y. (2006). Triosephosphate isomerase- and glyceraldehyde-3-phosphate dehydrogenase-reactive autoantibodies in the cerebrospinal fluid of patients with multiple sclerosis. Journal of Immunology, 177(8), 5652-8.

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Edzard Spillner