Publications

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Lund, A., Dorn, B., Jakob, T., Christensen, L. H., Jabs, F. & Spillner, E. (2025). A Fully Human Monoclonal Antibody Isolated From a Beekeeper Targets the Immunodominant IgE Epitope of Api m 10. Journal of Investigational Allergology and Clinical Immunology, 35(1), 55-57. https://doi.org/10.18176/jiaci.1029

Jensen, R. K., Miehe, M., Gandini, R., Jørgensen, M. H., Spillner, E. & Andersen, G. R. (2025). Cryo-EM Structure of FcεRI Bound IgE Reveals Multiple Defined Conformations of the Fab-Fc Hinge. Allergy: European Journal of Allergy and Clinical Immunology. Advance online publication. https://doi.org/10.1111/all.70132

Ballegaard, A. S. R., Jensen, B. K., Aagaard, J. B., Miehe, M. & Spillner, E. (2025). Molecular targeting in the context of insect venom allergy: targets and perspectives. Allergo Journal International. Advance online publication. https://doi.org/10.1007/s40629-025-00355-7

Aagaard, J. B., Fischer, M., Lober, J., Bolbro Neumann, F., Allahverdi, D., Sivelle, C., Miehe, M. & Spillner, E. (2023). Extract-shaped immune repertoires as source for nanobody-based human IgE in grass pollen allergy. Molecular Biotechnology, 65(9), 1518-1527. https://doi.org/10.1007/s12033-023-00664-8

Aagaard, J. B., Ballegaard, A.-S. R., Andersen, P. O. & Spillner, E. (2023). Molecular engineering of nanobodies as tools in allergology: diagnostics and beyond. Allergo Journal International, 32(7), 240-250. https://doi.org/10.1007/s40629-023-00261-w

Aagaard, J. B., Ballegaard, A.-S. R., Andersen, P. O. & Spillner, E. (2023). Molekulares Design von Nanobodies als Werkzeuge in der Allergologie: Diagnostik und mehr. Allergo Journal, 32, 29-40. https://doi.org/10.1007/s15007-023-5829-1

Romani Fernandez, L. G., Spillner, E. & Jakob, T. (2023). Potential and limitations of epitope mapping and molecular targeting in Hymenoptera venom allergy. Frontiers in Allergy, 4, Artikel 1327391. https://doi.org/10.3389/falgy.2023.1327391

Plum, M., Tjerrild, L., Raiber, T., Bantleon, F., Bantleon, S., Miehe, M., Jabs, F., Seismann, H., Möbs, C., Pfützner, W., Jakob, T., Andersen, G. R. & Spillner, E. (2023). Structural and functional analyses of antibodies specific for modified core N-glycans suggest a role in T_H2 responses. Allergy, 78(1), 121-130. https://doi.org/10.1111/all.15417

Pourjafar, M., Saidijam, M., Miehe, M., Najafi, R., Soleimani, M. & Spillner, E. (2023). Surfaceome Profiling Suggests Potential of Anti-MUC1×EGFR Bispecific Antibody for Breast Cancer Targeted Therapy. Journal of Immunotherapy, 46(7), 245-261. https://doi.org/10.1097/CJI.0000000000000482

Pourjafar, M., Miehe, M., Najafi, R., Soleimani, M. & Spillner, E. (2022). Construction, expression and functional characterization of an engineered antibody against tumor antigen MUC-1C. Protein Expression and Purification, 199, Artikel 106148. https://doi.org/10.1016/j.pep.2022.106148

Albrecht, M., Schaub, B., Gilles, S., Köhl, J., Altrichter, S., Voehringer, D., Spillner, E., Ehlers, M., Jönsson, F., Loser, K., Mayer, J. U., Rösner, L. M., Möbs, C., Heine, G. & Pfützner, W. (2022). Current research and unmet needs in allergy and immunology in Germany: report presented by the DGfI and DGAKI task force Allergy & Immunology. European Journal of Immunology, 52(6), 851-855. https://doi.org/10.1002/eji.202270065

Aagaard, J. B., Sivelle, C., Fischer, M., Byskov, K., Laursen, N. S., Pfützner, W., Jakob, T., Möbs, C., Miehe, M. & Spillner, E. (2022). Nanobody-based human antibody formats act as IgE surrogate in hymenoptera venom allergy. Allergy: European Journal of Allergy and Clinical Immunology, 77(9), 2859-2862. https://doi.org/10.1111/all.15391

Platts-Mills, T., Hilger, C., Jappe, U., van Hage, M., Gadermaier, G., Spillner, E., Lidholm, J., Aalberse, R. C., van Ree, R., Goodman, R. & Pomes, A. (2021). Carbohydrate Epitopes Currently Recognized as Targets for IgE Antibodies. Allergy: European Journal of Allergy and Clinical Immunology, 76(8), 2383-2394. https://doi.org/10.1111/all.14802.

Sonnenberg-Riethmacher, E., Miehe, M. & Riethmacher, D. (2021). Periostin in Allergy and Inflammation. Frontiers in Immunology, 12, Artikel 722170. https://doi.org/10.3389/fimmu.2021.722170

Strecker, C., Bärenfänger, M., Miehe, M., Spillner, E. & Meyer, B. (2020). In Silico Evaluation of the Binding Site of Fucosyltransferase 8 and First Attempts to Synthesize an Inhibitor with Drug-Like Properties. ChemBioChem, 21(13), 1923-1931. https://doi.org/10.1002/cbic.201900289

Jensen, R. K., Jabs, F., Miehe, M., Mølgaard, B., Pfützner, W., Möbs, C., Spillner, E. & Andersen, G. R. (2020). Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy. Allergy: European Journal of Allergy and Clinical Immunology, 75(8), 1952-1961. https://doi.org/10.1111/all.14222

Rauber, M., Roßbach, A., Jung, A., Müller, S., Möbs, C., Pfützner, W., Miehe, M., Spillner, E. & Jakob, T. (2020). The honey bee venom allergen Api m 10 displays one major IgE epitope, Api m 10160-174. Allergy: European Journal of Allergy and Clinical Immunology, 75(7), 1756-1759. https://doi.org/10.1111/all.14187

Jakob, T., Rauber, M. M., Perez-Riverol, A., Spillner, E. & Blank, S. (2020). The Honeybee Venom Major Allergen Api m 10 (Icarapin) and Its Role in Diagnostics and Treatment of Hymenoptera Venom Allergy. Current Allergy and Asthma Reports, 20(9), Artikel 48. https://doi.org/10.1007/s11882-020-00943-3

Rasmussen, P., Spillner, E. & Hoffmann, H. J. (2019). Inhibiting phosphatase SHIP-1 enhances suboptimal IgE-mediated activation of human blood basophils but inhibits IgE-mediated activation of cultured human mast cells. Immunology Letters, 210, 40-46. https://doi.org/10.1016/j.imlet.2019.04.003

Vos, B. J. P. R., Dubois, A. E. J., Rauber, M. M., Pfützner, W., Miehe, M., Bohle, B., Möbs, C. & Oude Elberink, J. N. G. (2019). Initiating yellow jacket venom immunotherapy with a 100-μg dose: A challenge? The Journal of Allergy and Clinical Immunology: In Practice, 7(4), 1332-1334.e4. https://doi.org/10.1016/j.jaip.2018.09.005

Schmid, J. M., Skjold, T., Kolstad, H. A., Miehe, M., Spillner, E. & Hoffmann, H. J. (2019). Work-related allergic asthma: Clinical work-up of a 45-year old male working in animal feed producing industry. Allergy: European Journal of Allergy and Clinical Immunology, 74, 316-316.

Fazekas-Singer, J., Singer, J., Ilieva, K. M., Matz, M., Herrmann, I., Spillner, E., Karagiannis, S. N. & Jensen-Jarolim, E. (2018). AllergoOncology: Generating a canine anti-cancer IgE against the epidermal growth factor receptor. Journal of Allergy and Clinical Immunology, 142(3), 973-976.e11. https://doi.org/10.1016/j.jaci.2018.04.021

Russkamp, D., Van Vaerenbergh, M., Etzold, S., Eberlein, B., Darsow, U., Schiener, M., De Smet, L., Absmaier, M., Biedermann, T., Spillner, E., Ollert, M., Jakob, T., Schmidt-Weber, C. B., de Graaf, D. C. & Blank, S. (2018). Characterization of the honeybee venom proteins C1q-like protein and PVF1 and their allergenic potential. Toxicon, 150, 198-206. https://doi.org/10.1016/j.toxicon.2018.05.017

Perez Riverol, A., Romani Fernandes, L. G., Musacchio Lasa, A., Aparecido dos Santos-Pinto, J. R., Moitinho Abram, D., Izuka Moraes, G. H., Jabs, F., Miehe, M., Seismann, H., Sergio Palma, M., de Lima Zollner, R., Spillner, E. & Brochetto-Braga, M. R. (2018). Phospholipase A1-based cross-reactivity among venoms of clinically relevant Hymenoptera from Neotropical and temperate regions. Molecular Immunology, 93, 87-93. https://doi.org/10.1016/j.molimm.2017.11.007

Jabs, F., Plum, M., Laursen, N. S., Jensen, R. K., Mølgaard, B., Miehe, M., Mandolesi, M., Rauber, M. M., Pfützner, W., Jakob, T., Möbs, C., Andersen, G. R. & Spillner, E. (2018). Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction. Nature Communications, 9(1), Artikel 7. https://doi.org/10.1038/s41467-017-02312-7

Riverol, A. P., Miehe, M., Jabs, F., Seismann, H., Romani Fernandes, L. G., de Lima Zollner, R., Jakob, T., Brochetto-Braga, M. R. & Spillner, E. (2018). Venoms of Neotropical wasps lack cross-reactive carbohydrate determinants enabling reliable protein-based specific IgE determination. Journal of Allergy and Clinical Immunology, 141(5), 1917-1919.e1. https://doi.org/10.1016/j.jaci.2017.12.990

Jensen-Jarolim, E., Bax, HJ., Bianchini, R., Capron, M., Corrigan, C., Castells, M., Dombrovicz, D., Daniels-Wells, HR., Fazekas, J., Fiebiger, E., Gatault, S., Gould, H., Janda, J., Josephs, DH., Karagiannis, P., Levi-Schaffer, F., Meshcheryakova, A., Mechtcheriakova, D., Mekori, Y. ... Karagiannis, S. N. (2017). AllergoOncology - the Impact of Allergy in Oncology. EAACI Position Paper. Allergy: European Journal of Allergy and Clinical Immunology, 72(6), 866-887. https://doi.org/10.1111/all.13119

Jabs, F., Plum, M., Laursen, N. S., Jensen, R., Miehe, M., Moebs, C., Pfuetzner, W., Jakob, T., Andersen, G. R. & Spillner, E. (2017). An anti-IgE single domain antibody disrupts the interaction of IgE with fceri by acting as functional high affinity mimic of cd23. Allergy: European Journal of Allergy and Clinical Immunology, 72(Suppl. 103 SI), 13-13. Artikel 0138. https://doi.org/10.1111/all.13250

Schiener, M., Eberlein, B., Moreno Aguilar, C., Pietsch, G., Serrano, P., McIntyre, M., Schwarze, L., Russkamp, D., Biedermann, T., Spillner, E., Darsow, U., Ollert, M., Schmidt-Weber, C. & Blank, S. (2017). Application of recombinant antigen 5 allergens from seven allergy-relevant Hymenoptera species in diagnostics. Allergy: European Journal of Allergy and Clinical Immunology, 72(1), 98-108. https://doi.org/10.1111/all.13000

Offermann, N., Plum, M., Miehe, M., Hubner, U., Fooke, M. & Spillner, E. (2017). Artificial human sera (ARTHUS) as a tool for validation and standardization of bee and wasp specific in-vitro diagnostic systems. Allergy: European Journal of Allergy and Clinical Immunology, 72(S103 - Special Issue), 355-356. Artikel 1466. https://doi.org/10.1111/all.13248

Jakob, T., Blank, S. & Spillner, E. (2017). Benefits and limitations of recombinant allergens in diagnostics of insect venom allergy. I J. Kleine-Tebbe & T. Jakob (red.), Molecular Allergy Diagnostics: Innovation for a Better Patient Management (s. 341-362). Springer. https://doi.org/10.1007/978-3-319-42499-6_18

Jakob, T. & Spillner, E. (2017). Comparing sensitivity of Hymenoptera allergen components on different diagnostic assay systems: Comparing apples and oranges. Journal of Allergy and Clinical Immunology, 139(3), 1066-1067. https://doi.org/10.1016/j.jaci.2016.09.058

Jakob, T., Müller, U., Helbling, A. & Spillner, E. (2017). Component resolved diagnostics for Hymenoptera venom allergy. Current Opinion in Allergy and Clinical Immunology, 17(5), 363-372. https://doi.org/10.1097/ACI.0000000000000390

Jakob, T., Rafei-Shamsabadi, D., Spillner, E. & Müller, S. (2017). Diagnostics in hymenoptera venom allergy: Current concepts and developments with special focus on molecular allergy diagnostics. Allergo Journal International, 26(3), 93-105. https://doi.org/10.1007/s40629-017-0014-2

Miehe, M., Mandolesi, M., Jabs, F., Plum, M., Bantleon, F., Seismann, H., Moebs, C., Pfuetzner, W., Jakob, T. & Spillner, E. (2017). Facilitated allergen binding of venom allergens via CD23 mediated by CCD-specific IgE. Allergy: European Journal of Allergy and Clinical Immunology, 72(S103 - Special Issue), 815-815. https://doi.org/10.1111/all.13249

Pedersen, C. T., Loke, I., Lorentzen, A., Wolf, S., Kamble, M., Kristensen, S. K., Munch, D., Radutoiu, S., Spillner, E., Roepstorff, P., Thaysen-Andersen, M., Stougaard, J. & Dam, S. (2017). N-glycan maturation mutants in Lotus japonicus for basic and applied glycoprotein research. Plant Journal, 91(3), 394-407. https://doi.org/10.1111/tpj.13570

Bantleon, F., Wolf, S., Seismann, H., Dam, S. S., Lorentzen, A., Miehe, M., Jabs, F., Jakob, T., Plum, M. & Spillner, E. (2016). Human IgE is efficiently produced in glycosylated and biologically active form in lepidopteran cells. Molecular Immunology, 72, 49-56. https://doi.org/10.1016/j.molimm.2016.02.013

Offermann, N., Plum, M., Hübner, U., Rathloff, K., Braren, I., Fooke, M. & Spillner, E. (2016). Human serum substitution by artificial sera of scalable allergen reactivity based on polyclonal antibodies and chimeras of human FcγRI and IgE domains. Allergy: European Journal of Allergy and Clinical Immunology, 71(12), 1794-1799. https://doi.org/10.1111/all.13038

Jakob, T., Spillner, E. & Lamers, M. (2016). IgE als Zielstruktur für therapeutische Intervention. I T. Biedermann, H. Renz, W. Heppt & M. Röcken (red.), Allergologie (s. 631-640). Springer. https://doi.org/10.1007/978-3-642-37203-2_58

Frick, M., Fischer, J., Helbing, A., Ruëff, F., Wieczorek, D., Ollert, M., Pfützner, W., Müller, S., Huss-Marp, J., Dorn, B., Biedermann, T., Lidholm, J., Rücker, G., Bantleon, F., Miehe, M., Spillner, E. & Jakob, T. (2016). Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy. Journal of Allergy and Clinical Immunology, 138(6), 1663-1671e9. https://doi.org/10.1016/j.jaci.2016.04.024

Spillner, E. (2016). Recombinant allergens as a major step in molecular allergology: Scientific and methodological considerations. I M. Kosnik & R. Marcun (red.), Slovenian Pneumology and Allergology Congress joined with Golnik Symposium and Balkan Pneumology Meeting: Personalised Medicine in Respiratory and Immunologic Diseases - Book of Abstacts (s. 77-81). University Clinic of Respiratory and Allergic Diseases, Golnik. http://www.klinika-golnik.si/uploads/si/strokovna-javnost/strokovne-publikacije/6-slovenian-pneumology-congress-book-of-abstracts-194.pdf

Möbs, C., Müller, J., Rudzio, A., Pickert, J., Blank, S., Jakob, T., Spillner, E. & Pfützner, W. (2015). Decline of Ves v 5-specific blocking capacity in wasp venom-allergic patients after stopping allergen immunotherapy. Allergy: European Journal of Allergy and Clinical Immunology, 6. https://doi.org/10.1111/all.12606

Spillner, E. (2015). Diagnostik der Insektengiftallergie: vom Extrakt zum Molekül. Spitzenforschung in der Allergologie, 2015, 92-93.

Van Vaerenbergh, M., de Smet, L., Rafei-Shamsabadi, D., Blank, S., Spillner, E., Ebo, D., Devreese, B., Jakob, T. & C. de Graaf, D. (2015). IgE recognition of chimeric isoforms of the honeybee (Apis mellifera) venom allergen Api m 10 evaluated by protein array technology. Molecular Immunology, 63(2), 449-455. https://doi.org/10.1016/j.molimm.2014.09.018

Jakob, T., Blank, S. & Spillner, E. (2015). Optimierte Diagnostik der Insektengiftallergie durch rekombinante Allergene. I J. Kleine-Tebbe & T. Jakob (red.), Molekulare Allergiediagnostik (s. 257-275). Springer. https://doi.org/10.1007/978-3-662-45221-9_16

Sonnenberg-Riethmacher, E., Miehe, M. & Riethmacher, D. (2015). Promotion of periostin expression contributes to the migration of Schwann cells. Journal of Cell Science, 128(17), 3345-3355. https://doi.org/10.1242/jcs.174177

Frick, M., Müller, S., Bantleon, F., Hus-Marp, J., Lidholm, J., Spillner, E. & Jakob, T. (2015). rApi m 3 and rApi m 10 improve detection of honey bee sensitization in Hymenoptera venom-allergic patients with double sensitization to honey bee and yellow jacket venom. Allergy: European Journal of Allergy and Clinical Immunology, 70(12), 1665-1668. https://doi.org/10.1111/all.12725

Jensen, R. K., Plum, M., Tjerrild, L., Jakob, T., Spillner, E. & Andersen, G. R. (2015). Structure of the omalizumab Fab. Acta Crystallographica Section F: Structural Biology Communications, 71(Pt 4), 419-426. https://doi.org/10.1107/S2053230X15004100

Jakob, T., Müller, S., Rafei-Shamsabadi, D., Bantleon, F. & Spillner, E. (2014). Aktueller Stand und neue Entwicklungen in der Diagnostik mit rekombinanten Insektengiftallergenen. Allergologie, 37(9), 352-361.

Balzer, L., Pennino, D., Blank, S., Seismann, H., Darsow, U., Schnedler, M., McIntyre, M., Ollert, M., Durham, S. R., Spillner, E., Ring, J. & Cifuentes, L. (2014). Basophil activation test using recombinant allergens: highly specific diagnostic method complementing routine tests in wasp venom allergy. PLoS One, 9(10), e108619. https://doi.org/10.1371/journal.pone.0108619

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Revideret 13.11.2025

Edzard Spillner