Publications

Sort by: Date | Author | Title

Liebau, E., Spillner, E. & Henkle-Dührsen, K. (1997). pOVEX vector: Prokaryotic expression and purification of onchocerciasis vaccine candidate antigens as fusion proteins with the 24 kD Onchocerca volvulus glutathione S-transferase. Tropical Medicine & International Health, 2(7), 691-694.

Kötzler, M. P., Blank, S., Bantleon, F. I., Wienke, M., Spillner, E. & Meyer, B. (2013). Donor assists acceptor binding and catalysis of human α1,6-fucosyltransferase. A C S Chemical Biology, 8(8), 1830-40. https://doi.org/10.1021/cb400140u

Kötzler, M. P., Blank, S., Bantleon, F. I., Spillner, E. & Meyer, B. (2012). Donor substrate binding and enzymatic mechanism of human core α1,6-fucosyltransferase (FUT8). B B A - General Subjects, 1820(12), 1915-1925. https://doi.org/10.1016/j.bbagen.2012.08.018

Kötzler, M. P., Blank, S., Behnken, H. N., Alpers, D., Bantleon, F. I., Spillner, E. & Meyer, B. (2012). Formation of the immunogenic α1,3-fucose epitope: elucidation of substrate specificity and of enzyme mechanism of core fucosyltransferase A. Insect Biochemistry and Molecular Biology, 42(2), 116-25. https://doi.org/10.1016/j.ibmb.2011.11.004

Kölln, J., Braren, I., Bredehorst, R. & Spillner, E. (2007). Purification of native and recombinant cobra venom factor using thiophilic adsorption chromatography. Protein and Peptide Letters, 14(5), 475-80.

Kölln, J., Bredehorst, R. & Spillner, E. (2005). Engineering of human complement component C3 for catalytic inhibition of complement. Immunology Letters, 98(1), 49-56. https://doi.org/10.1016/j.imlet.2004.10.010

Kölln, J., Spillner, E., Andrä, J., Klensang, K. & Bredehorst, R. (2004). Complement inactivation by recombinant human C3 derivatives. Journal of Immunology, 173(9), 5540-5.

Kölln, J., Matzas, M., Jänner, N., Mix, T., Klensang, K., Bredehorst, R. & Spillner, E. (2004). Functional analysis of Cobra Venom Factor/human C3 chimeras transiently expressed in mammalian cells. Molecular Immunology, 41(1), 19-28. https://doi.org/10.1016/j.molimm.2004.02.003

Kölln, J., Spillner, E. & Bredehorst, R. (2005). Complement depletion using recombinant human C3-derivatives.

Kolln, J., Ren, H.-M., Da, R.-R., Zhang, Y., Spillner, E., Olek, M., Hermanowicz, N., Hilgenberg, L. G., Smith, M. A., van den Noort, S. & Qin, Y. (2006). Triosephosphate isomerase- and glyceraldehyde-3-phosphate dehydrogenase-reactive autoantibodies in the cerebrospinal fluid of patients with multiple sclerosis. Journal of Immunology, 177(8), 5652-8.

Köhler, J., Blank, S., Müller, S., Bantleon, F., Frick, M., Huss-Marp, J., Lidholm, J., Spillner, E. & Jakob, T. (2014). Component resolution reveals additional major allergens in patients with honeybee venom allergy. Journal of Allergy and Clinical Immunology, 133(5), 1383-1389.e6. https://doi.org/10.1016/j.jaci.2013.10.060

Jensen-Jarolim, E., Bax, HJ., Bianchini, R., Capron, M., Corrigan, C., Castells, M., Dombrovicz, D., Daniels-Wells, HR., Fazekas, J., Fiebiger, E., Gatault, S., Gould, H., Janda, J., Josephs, DH., Karagiannis, P., Levi-Schaffer, F., Meshcheryakova, A., Mechtcheriakova, D., Mekori, Y. ... Karagiannis, S. N. (2017). AllergoOncology - the Impact of Allergy in Oncology. EAACI Position Paper. Allergy: European Journal of Allergy and Clinical Immunology, 72(6), 866-887. https://doi.org/10.1111/all.13119

Jensen, R. K., Plum, M., Tjerrild, L., Jakob, T., Spillner, E. & Andersen, G. R. (2015). Structure of the omalizumab Fab. Acta Crystallographica Section F: Structural Biology Communications, 71(Pt 4), 419-426. https://doi.org/10.1107/S2053230X15004100

Jensen, R. K., Jabs, F., Miehe, M., Mølgaard, B., Pfützner, W., Möbs, C., Spillner, E. & Andersen, G. R. (2020). Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy. Allergy: European Journal of Allergy and Clinical Immunology, 75(8), 1952-1961. https://doi.org/10.1111/all.14222

Jensen, R. K., Miehe, M., Gandini, R., Jørgensen, M. H., Spillner, E. & Andersen, G. R. (2025). Cryo-EM Structure of FcεRI Bound IgE Reveals Multiple Defined Conformations of the Fab-Fc Hinge. Allergy: European Journal of Allergy and Clinical Immunology. Advance online publication. https://doi.org/10.1111/all.70132

Jakob, T., Blank, S., Spillner, E. & Ollert, M. (2011). Rekombinante Insektengift-Allergene: Ist das Bienen- oder doch das Wespengift schuld? Der Deutsche Dermatologe, 59, 759-761.

Jakob, T., Köhler, J., Blank, S., Spillner, E., Magnusson, U., Lidholm, J. & Huss-Marp, J. (2012). Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant-negative patients with bee venom allergy. Journal of Allergy and Clinical Immunology, 130(1), 276-278. https://doi.org/10.1016/j.jaci.2012.03.048

Jakob, T., Spillner, E. & Lamers, M. (2016). IgE als Zielstruktur für therapeutische Intervention. In T. Biedermann, H. Renz, W. Heppt & M. Röcken (Eds.), Allergologie (pp. 631-640). Springer. https://doi.org/10.1007/978-3-642-37203-2_58

Jakob, T., Blank, S. & Spillner, E. (2015). Optimierte Diagnostik der Insektengiftallergie durch rekombinante Allergene. In J. Kleine-Tebbe & T. Jakob (Eds.), Molekulare Allergiediagnostik (pp. 257-275). Springer. https://doi.org/10.1007/978-3-662-45221-9_16

Jakob, T., Müller, S., Rafei-Shamsabadi, D., Bantleon, F. & Spillner, E. (2014). Aktueller Stand und neue Entwicklungen in der Diagnostik mit rekombinanten Insektengiftallergenen. Allergologie, 37(9), 352-361.

Jakob, T., Blank, S. & Spillner, E. (2017). Benefits and limitations of recombinant allergens in diagnostics of insect venom allergy. In J. Kleine-Tebbe & T. Jakob (Eds.), Molecular Allergy Diagnostics: Innovation for a Better Patient Management (pp. 341-362). Springer. https://doi.org/10.1007/978-3-319-42499-6_18

Jakob, T., Rafei-Shamsabadi, D., Spillner, E. & Müller, S. (2017). Diagnostics in hymenoptera venom allergy: Current concepts and developments with special focus on molecular allergy diagnostics. Allergo Journal International, 26(3), 93-105. https://doi.org/10.1007/s40629-017-0014-2

Jakob, T. & Spillner, E. (2017). Comparing sensitivity of Hymenoptera allergen components on different diagnostic assay systems: Comparing apples and oranges. Journal of Allergy and Clinical Immunology, 139(3), 1066-1067. https://doi.org/10.1016/j.jaci.2016.09.058

Jakob, T., Müller, U., Helbling, A. & Spillner, E. (2017). Component resolved diagnostics for Hymenoptera venom allergy. Current Opinion in Allergy and Clinical Immunology, 17(5), 363-372. https://doi.org/10.1097/ACI.0000000000000390

Jakob, T., Rauber, M. M., Perez-Riverol, A., Spillner, E. & Blank, S. (2020). The Honeybee Venom Major Allergen Api m 10 (Icarapin) and Its Role in Diagnostics and Treatment of Hymenoptera Venom Allergy. Current Allergy and Asthma Reports, 20(9), Article 48. https://doi.org/10.1007/s11882-020-00943-3

Jabs, F., Plum, M., Laursen, N. S., Jensen, R. K., Mølgaard, B., Miehe, M., Mandolesi, M., Rauber, M. M., Pfützner, W., Jakob, T., Möbs, C., Andersen, G. R. & Spillner, E. (2018). Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction. Nature Communications, 9(1), Article 7. https://doi.org/10.1038/s41467-017-02312-7

Jabs, F., Plum, M., Laursen, N. S., Jensen, R., Miehe, M., Moebs, C., Pfuetzner, W., Jakob, T., Andersen, G. R. & Spillner, E. (2017). An anti-IgE single domain antibody disrupts the interaction of IgE with fceri by acting as functional high affinity mimic of cd23. Allergy: European Journal of Allergy and Clinical Immunology, 72(Suppl. 103 SI), 13-13. Article 0138. https://doi.org/10.1111/all.13250

Hofmann, S. C., Pfender, N., Weckesser, S., Jakob, T., Blank, S., Spillner, E. & Huss-Marp, J. (2011). Reply. Journal of Allergy and Clinical Immunology, 128(1), 248. https://doi.org/10.1016/j.jaci.2011.02.020

Hecker, J., Diethers, A., Schulz, D., Sabri, A., Plum, M., Michel, Y., Mempel, M., Ollert, M., Jakob, T., Blank, S., Braren, I. & Spillner, E. (2012). An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE. Allergy: European Journal of Allergy and Clinical Immunology, 67(12), 1530-1537. https://doi.org/10.1111/all.12045

Hecker, J., Diethers, A., Seismann, H., Michel, Y., Plum, M., Bredehorst, R., Blank, S., Etzold, S., Braren, I. & Spillner, E. (2011). Generation and epitope analysis of human monoclonal antibody isotypes with specificity for the timothy grass major allergen Phl p 5a. Molecular Immunology, 48(9-10), 1236-1244. https://doi.org/10.1016/j.molimm.2011.03.005

Grunwald, T., Bockisch, B., Spillner, E., Bredehorst, R., Ring, J. & Ollert, M. W. (2006). Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3). Journal of Allergy and Clinical Immunology, 117(4), 848-854. https://doi.org/10.1016/j.jaci.2005.12.1331

Greunke, K., Braren, I., Alpers, I., Blank, S., Sodenkamp, J., Bredehorst, R. & Spillner, E. (2008). Recombinant IgY for improvement of immunoglobulin-based analytical applications. Clinical Biochemistry, 41(14-15), 1237-44. https://doi.org/10.1016/j.clinbiochem.2008.07.004

Greunke, K., Spillner, E., Braren, I., Seismann, H., Kainz, S., Hahn, U., Grunwald, T. & Bredehorst, R. (2006). Bivalent monoclonal IgY antibody formats by conversion of recombinant antibody fragments. Journal of Biotechnology, 124(2), 446-56. https://doi.org/10.1016/j.jbiotec.2005.12.032

Gorjanović, S., Beljanski, M. V., Pavlović, M., Spillner, E., Gorjanović, R. & Gojgić-Cvijanović, G. (2005). Malting barley grain non-specific lipid-transfer protein (ns-LTP): Importance for grain protection. Journal of the Institute of Brewing, 111(2), 99-104.

Frick, M., Müller, S., Bantleon, F., Hus-Marp, J., Lidholm, J., Spillner, E. & Jakob, T. (2015). rApi m 3 and rApi m 10 improve detection of honey bee sensitization in Hymenoptera venom-allergic patients with double sensitization to honey bee and yellow jacket venom. Allergy: European Journal of Allergy and Clinical Immunology, 70(12), 1665-1668. https://doi.org/10.1111/all.12725

Frick, M., Fischer, J., Helbing, A., Ruëff, F., Wieczorek, D., Ollert, M., Pfützner, W., Müller, S., Huss-Marp, J., Dorn, B., Biedermann, T., Lidholm, J., Rücker, G., Bantleon, F., Miehe, M., Spillner, E. & Jakob, T. (2016). Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy. Journal of Allergy and Clinical Immunology, 138(6), 1663-1671e9. https://doi.org/10.1016/j.jaci.2016.04.024

Fazekas-Singer, J., Singer, J., Ilieva, K. M., Matz, M., Herrmann, I., Spillner, E., Karagiannis, S. N. & Jensen-Jarolim, E. (2018). AllergoOncology: Generating a canine anti-cancer IgE against the epidermal growth factor receptor. Journal of Allergy and Clinical Immunology, 142(3), 973-976.e11. https://doi.org/10.1016/j.jaci.2018.04.021

Deckers, S., Braren, I., Greunke, K., Meyer, N., Rühl, D., Bredehorst, R. & Spillner, E. (2009). Establishment of hapten-specific monoclonal avian IgY by conversion of antibody fragments obtained from combinatorial libraries. Biotechnology and Applied Biochemistry, 52(Pt 1), 79-87. https://doi.org/10.1042/BA20080032

Cifuentes, L., Vosseler, S., Blank, S., Seismann, H., Grunwald, T., Darsow, U., Bredehorst, R., Mempel, M., Spillner, E., Ring, J. & Ollert, M. (2014). Identification of hymenoptera venom-allergic patients with negative specific IgE to venom extract by using recombinant allergens. Journal of Allergy and Clinical Immunology, 133(3), 909-910.

Cámpora, J., López, J. A., Palma, P., Spillner, E., Carmona, E. & Valerga, P. (1999). Cleavage of palladium metallacycles by acids: A probe for the study of the cyclometalation reaction. Angewandte Chemie International Edition, 38(1-2), 147-151.

Bredehorst, R., Grunwald, T., Ollert, M. W., Schmidt-Weber, C. & Spillner, E. (2014). Selective local inhibition of TNFR1-mediated functions at the site of antigen/allergen presentation.

Bredehorst, R., Grunwald, T., Ollert, M., Schmidt-Weber, C. & Spillner, E. (2013). Controlled activation of complement components for use as endogenous adjuvant.

Bredehorst, R., Grunwald, T., Ollert, M., Schmidt-Weber, C. & Spillner, E. (2013). Modulation of effector T cell responses by local depletion of complement component C3.

Bredehorst, R., Greunke, K., Grunwald, T. & Spillner, E. (2007). Bivalent IgY antibody constructs for diagnostic and therapeutic applications.

Bredehorst, R., Glökler, J., Grunwald, T., Matzas, M. & Spillner, E. (2007). Method for determining an unknown PNA [peptide nucleic acid] sequence and uses thereof.

Braren, I., Greunke, K., Grunwald, T., Pilette, C., Mempel, M., Bredehorst, R., Ring, J., Spillner, E. & Ollert, M. (2011). Quantitation of serum IgE by using chimeras of human IgE receptor and avian immunoglobulin domains. Analytical Biochemistry, 412(2), 134-140. https://doi.org/10.1016/j.ab.2010.12.013

Braren, I., Blank, S., Seismann, H., Deckers, S., Ollert, M., Grunwald, T. & Spillner, E. (2007). Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries. Clinical Chemistry, 53(5), 837-44. https://doi.org/10.1373/clinchem.2006.078360

Braren, I., Greunke, K., Umland, O., Deckers, S., Bredehorst, R. & Spillner, E. (2007). Comparative expression of different antibody formats in mammalian cells and Pichia pastoris. Biotechnology and Applied Biochemistry, 47(4), 205-14. https://doi.org/10.1042/BA20060170

Braren, I., Bredehorst, R., Ollert, M., Grunwald, T., Spillner, E. & Ring, J. (2009). Antibody compositions specific for IgE, IgG4 and IgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy.

Bockisch, B., Grunwald, T., Spillner, E. & Bredehorst, R. (2005). Immobilized stem-loop structured probes as conformational switches for enzymatic detection of microbial 16S rRNA. Nucleic Acids Research, 33(11), Article e101. https://doi.org/10.1093/nar/gni101

Displaying results 51 to 100 out of 116

Revised 13.11.2025

Edzard Spillner