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Institut for Bio- og Kemiteknologi

Publications by Medical Biotechnology

Are you looking for publications by Section of Medical Biotechnology? On this page you can find all the publications made by the Section of Medical Biotechnology - Department of Biological & Chemical Engineering, Aarhus University.

Below you can find a list of all the publications, their publishing date, their author(s), and titles. The list can be sorted by date, author, and title:

List of Publications

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Jiang, Z., Li, J., Aslan, H., Li, Q., Li, Y., Chen, M., Huang, Y., Froning, J. P., Otyepka, M., Zbořil, R., Besenbacher, F. & Dong, MD. (2014). A high eﬃciency H₂S gas sensor material: paper like Fe₂O₃/graphene nanosheets and structural alignment dependency of device eﬃciency. Journal of Materials Chemistry A, 2, 6714–6717. https://doi.org/10.1039/c3ta15180h

Li, Y. Y., Femenias, M. R., Aslan, H. H., Yu, Y. Y., Howard, K., Dong, MD., Besenbacher, F. F. & Chen, M. M. (2014). Ultraporous interweaving electrospun microfibers from PCL-PEO binary blends and their inflammatory responses. Nanoscale, 6(6), 3392-3402. https://doi.org/10.1039/c3nr06197c

Rafei-Shamsabadi, D., Müller, S., Pfützner, W., Spillner, E., Rueff, F. & Jakob, T. (2014). Recombinant allergens rarely allow identification of Hymenoptera venom-allergic patients with negative specific IgE to whole venom preparations. Journal of Allergy and Clinical Immunology, 134(2), 493-494. https://doi.org/10.1016/j.jaci.2014.05.035

Singer, J., Fazekas, J., Wang, W., Weichselbaumer, M., Matz, M., Mader, A., Steinfellner, W., Meitz, S., Mechticheriakova, D., Sobanov, J., Willmann, M., Stockner, T., Spillner, E., Kunert, R. & Jensen-Jarolim, E. (2014). Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. Molecular Cancer Therapeutics, 13(7), 1777-1790. https://doi.org/10.1158/1535-7163.MCT-13-0288

Spillner, E., Blank, S. & Jakob, T. (2014). Hymenoptera allergens: from venom to ”venome”. Frontiers in Immunology, 5(77). https://doi.org/10.3389/fimmu.2014.00077

Justesen, J., Mosekilde, L., Holmes, M., Stenderup, K., Gasser, J., Mullins, J. J., Seckl, J. R. & Kassem, M. (2004). Mice deficient in 11beta-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation. Endocrinology, 145(4), 1916-25. https://doi.org/10.1210/en.2003-1427

Laugesen, I. G., Hauge, E., Andersen, S. M., Stenderup, K., de Darkó, E., Dam, T. N. & Rosada, C. (2013). Valrubicin activates PKCa in keratinocytes: a conceivable mode of action in treating hyper-proliferative skin diseases. Journal of Drugs in Dermatology, 12(10), 1156-62.

Boote, C., Dooley, E. P., Gardner, S. J., Kamma-Lorger, C. S., Hayes, S., Nielsen, K., Hjortdal, J., Sørensen, T. L.-M., Terrill, N. J. & Meek, K. M. (2013). Quantification of collagen ultrastructure after penetrating keratoplasty - implications for corneal biomechanics. PLOS ONE, 8(7), e68166. https://doi.org/10.1371/journal.pone.0068166

Wittenborn, T. R., Larsen, E. K. U., Nielsen, T., Rydtoft, L. M., Hansen, L., Nygaard, J. V., Vorup-Jensen, T., Kjems, J., Horsman, M. R. & Nielsen, N. C. (2014). Accumulation of nano-sized particles in a murine model of angiogenesis. Biochemical and Biophysical Research Communications, 443(2), 470-6. https://doi.org/10.1016/j.bbrc.2013.11.127

Kang, R., Luo, Y., Zou, L., Xie, L., Lysdahl, H., Jiang, X., Chen, C., Bolund, L., Chen, M., Besenbacher, F. & Bunger, C. E. (2014). Oesteogenesis of Human Induced Pluripotent Stem Cells Derived Mesenchymal Stem Cells on hydroxyapatite contained Nanofibers. R S C Advances, 4(11), 5734-5739. https://doi.org/10.1039/C3RA44181D

Cifuentes, L., Vosseler, S., Blank, S., Seismann, H., Grunwald, T., Darsow, U., Bredehorst, R., Mempel, M., Spillner, E., Ring, J. & Ollert, M. (2014). Identification of hymenoptera venom-allergic patients with negative specific IgE to venom extract by using recombinant allergens. Journal of Allergy and Clinical Immunology, 133(3), 909-910.

Köhler, J., Blank, S., Müller, S., Bantleon, F., Frick, M., Huss-Marp, J., Lidholm, J., Spillner, E. & Jakob, T. (2014). Component resolution reveals additional major allergens in patients with honeybee venom allergy. Journal of Allergy and Clinical Immunology, 133(5), 1383-1389.e6. https://doi.org/10.1016/j.jaci.2013.10.060

Hofmann, S. C., Pfender, N., Weckesser, S., Jakob, T., Blank, S., Spillner, E. & Huss-Marp, J. (2011). Reply. Journal of Allergy and Clinical Immunology, 128(1), 248. https://doi.org/10.1016/j.jaci.2011.02.020

Liebau, E., Spillner, E. & Henkle-Dührsen, K. (1997). pOVEX vector: Prokaryotic expression and purification of onchocerciasis vaccine candidate antigens as fusion proteins with the 24 kD Onchocerca volvulus glutathione S-transferase. Tropical Medicine & International Health, 2(7), 691-694.

Cámpora, J., López, J. A., Palma, P., Spillner, E., Carmona, E. & Valerga, P. (1999). Cleavage of palladium metallacycles by acids: A probe for the study of the cyclometalation reaction. Angewandte Chemie International Edition, 38(1-2), 147-151.

Spillner, E. (2002). Selektion und Expression von rekombinanten Antikörpern für analytische und therapeutische Applikationen. Cuvillier Verlag.

Spillner, E., Deckers, S., Grunwald, T. & Bredehorst, R. (2003). Paratope-based protein identification by antibody and peptide phage display. Analytical Biochemistry, 321(1), 96-104.

Kölln, J., Matzas, M., Jänner, N., Mix, T., Klensang, K., Bredehorst, R. & Spillner, E. (2004). Functional analysis of Cobra Venom Factor/human C3 chimeras transiently expressed in mammalian cells. Molecular Immunology, 41(1), 19-28. https://doi.org/10.1016/j.molimm.2004.02.003

Kölln, J., Spillner, E., Andrä, J., Klensang, K. & Bredehorst, R. (2004). Complement inactivation by recombinant human C3 derivatives. Journal of Immunology, 173(9), 5540-5.

Łoś, M., Łoś, J. M., Blohm, L., Spillner, E., Grunwald, T., Albers, J., Hintsche, R. & Wegrzyn, G. (2005). Rapid detection of viruses using electrical biochips and anti-virion sera. Letters in Applied Microbiology, 40(6), 479-85. https://doi.org/10.1111/j.1472-765X.2005.01706.x

Gorjanović, S., Beljanski, M. V., Pavlović, M., Spillner, E., Gorjanović, R. & Gojgić-Cvijanović, G. (2005). Malting barley grain non-specific lipid-transfer protein (ns-LTP): Importance for grain protection. Journal of the Institute of Brewing, 111(2), 99-104.

Kölln, J., Bredehorst, R. & Spillner, E. (2005). Engineering of human complement component C3 for catalytic inhibition of complement. Immunology Letters, 98(1), 49-56. https://doi.org/10.1016/j.imlet.2004.10.010

Bockisch, B., Grunwald, T., Spillner, E. & Bredehorst, R. (2005). Immobilized stem-loop structured probes as conformational switches for enzymatic detection of microbial 16S rRNA. Nucleic Acids Research, 33(11), Artikel e101. https://doi.org/10.1093/nar/gni101

Münster, J., Ziegelmüller, P., Spillner, E. & Bredehorst, R. (2006). High level expression of monomeric and dimeric human alpha1,3-fucosyltransferase V. Journal of Biotechnology, 121(4), 448-57. https://doi.org/10.1016/j.jbiotec.2005.08.015

Greunke, K., Spillner, E., Braren, I., Seismann, H., Kainz, S., Hahn, U., Grunwald, T. & Bredehorst, R. (2006). Bivalent monoclonal IgY antibody formats by conversion of recombinant antibody fragments. Journal of Biotechnology, 124(2), 446-56. https://doi.org/10.1016/j.jbiotec.2005.12.032

Kolln, J., Ren, H.-M., Da, R.-R., Zhang, Y., Spillner, E., Olek, M., Hermanowicz, N., Hilgenberg, L. G., Smith, M. A., van den Noort, S. & Qin, Y. (2006). Triosephosphate isomerase- and glyceraldehyde-3-phosphate dehydrogenase-reactive autoantibodies in the cerebrospinal fluid of patients with multiple sclerosis. Journal of Immunology, 177(8), 5652-8.

Braren, I., Greunke, K., Umland, O., Deckers, S., Bredehorst, R. & Spillner, E. (2007). Comparative expression of different antibody formats in mammalian cells and Pichia pastoris. Biotechnology and Applied Biochemistry, 47(4), 205-14. https://doi.org/10.1042/BA20060170

Kölln, J., Braren, I., Bredehorst, R. & Spillner, E. (2007). Purification of native and recombinant cobra venom factor using thiophilic adsorption chromatography. Protein and Peptide Letters, 14(5), 475-80.

Braren, I., Blank, S., Seismann, H., Deckers, S., Ollert, M., Grunwald, T. & Spillner, E. (2007). Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries. Clinical Chemistry, 53(5), 837-44. https://doi.org/10.1373/clinchem.2006.078360

Deckers, S., Braren, I., Greunke, K., Meyer, N., Rühl, D., Bredehorst, R. & Spillner, E. (2009). Establishment of hapten-specific monoclonal avian IgY by conversion of antibody fragments obtained from combinatorial libraries. Biotechnology and Applied Biochemistry, 52(Pt 1), 79-87. https://doi.org/10.1042/BA20080032

Greunke, K., Braren, I., Alpers, I., Blank, S., Sodenkamp, J., Bredehorst, R. & Spillner, E. (2008). Recombinant IgY for improvement of immunoglobulin-based analytical applications. Clinical Biochemistry, 41(14-15), 1237-44. https://doi.org/10.1016/j.clinbiochem.2008.07.004

Seismann, H., Blank, S., Braren, I., Greunke, K., Cifuentes, L., Grunwald, T., Bredehorst, R., Ollert, M. & Spillner, E. (2010). Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation. Molecular immunology, 47(4), 799-808. https://doi.org/10.1016/j.molimm.2009.10.005

Spillner, E., Laursen, N. S., Christensen, J. B., Jensen, M., Fredslund, F., Sottrup-Jensen, L., Andersen, G. R., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Fraser, J. D., Wines, B. & Bjerre, M. (2010). Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus. Proceedings of the National Academy of Sciences (PNAS), 107(8), 3681-3686. https://doi.org/10.1073/pnas.0910565107

Blank, S., Seismann, H., Bockisch, B., Rühl, D., Bredehorst, R., Braren, I., Grunwald, T., Cifuentes, L., McIntyre, M., Ring, J., Ollert, M. W. & Spillner, E. (2010). Identification, recombinant expression, and characterization of the 100 kDa high molecular weight hymenoptera venom allergens Api m 5 and Ves v 3. Journal of Immunology, 184(9), 5403-5413. https://doi.org/10.4049/jimmunol.0803709

Seismann, H., Blank, S., Cifuentes, L., Braren, I., Bredehorst, R., Grunwald, T., Ollert, M. & Spillner, E. (2010). Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivity. Clinical and Molecular Allergy, 8. https://doi.org/10.1186/1476-7961-8-7

Spillner, E., Laursen, N. S., Andersen, K. R., Sottrup-Jensen, L., Andersen, G. R. & Braren, I. (2011). Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. E M B O Journal, 30(3), 606-616. https://doi.org/10.1038/emboj.2010.341

Jensen, J., Rölfing, J. H. D., Svend Le, D. Q., Kristiansen, A. A., Nygaard, J. V., Hokland, L. B., Bendtsen, M., Kassem, M., Lysdahl, H. & Bünger, C. (2014). Surface-modified functionalized polycaprolactone scaffolds for bone repair: In vitro and in vivo experiments. Journal of Biomedical Materials Research. Part A, 102(9), 2993-3003. https://doi.org/10.1002/jbm.a.34970

Binder, M., Léchenne, B., Ummanni, R., Balabanov, S., Trepel, M., Scharf, C., Trusch, M., Schlüter, H., Braren, I. & Spillner, E. (2010). Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells. P L o S One, 5(12), Artikel e15992. https://doi.org/10.1371/journal.pone.0015992

Braren, I., Greunke, K., Grunwald, T., Pilette, C., Mempel, M., Bredehorst, R., Ring, J., Spillner, E. & Ollert, M. (2011). Quantitation of serum IgE by using chimeras of human IgE receptor and avian immunoglobulin domains. Analytical Biochemistry, 412(2), 134-140. https://doi.org/10.1016/j.ab.2010.12.013

Grunwald, T., Bockisch, B., Spillner, E., Bredehorst, R., Ring, J. & Ollert, M. W. (2006). Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3). Journal of Allergy and Clinical Immunology, 117(4), 848-854. https://doi.org/10.1016/j.jaci.2005.12.1331

Sturm, G. J., Bokanovic, D., Aberer, W., Hemmer, W., Hawranek, T., Lang, R., Ollert, M., Spillner, E. & Blank, S. (2011). Detection of IgE to recombinant Api m 1 and rVes v 5 is valuable but not sufficient to distinguish bee from wasp venom allergy. Journal of Allergy and Clinical Immunology, 128(1), 247-248. https://doi.org/10.1016/j.jaci.2011.02.021

Blank, S., Seismann, H., Michel, Y., McIntyre, M., Cifuentes, L., Braren, I., Grunwald, T., Darsow, U., Ring, J., Bredehorst, R., Ollert, M. & Spillner, E. (2011). Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extracts. Allergy: European Journal of Allergy and Clinical Immunology, 66(10), 1322-1329. https://doi.org/10.1111/j.1398-9995.2011.02667.x

Wehr, C., Müller, F., Schüler, J., Tomann, T., Nitschke, C., Seismann, H., Spillner, E., Klingner, K., Schneider-Merck, T., Binder, M., Fiebig, H.-H., Mertelsmann, R. & Trepel, M. (2012). Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model. International Journal of Cancer, 131(2), E10-20. https://doi.org/10.1002/ijc.26464

Kötzler, M. P., Blank, S., Behnken, H. N., Alpers, D., Bantleon, F. I., Spillner, E. & Meyer, B. (2012). Formation of the immunogenic α1,3-fucose epitope: elucidation of substrate specificity and of enzyme mechanism of core fucosyltransferase A. Insect Biochemistry and Molecular Biology, 42(2), 116-25. https://doi.org/10.1016/j.ibmb.2011.11.004

Blank, S., Bantleon, F. I., Ollert, M., McIntyre, M. & Spillner, E. (2012). The major royal jelly proteins 8 and 9 (Api m 11) are glycosylated components of Apis mellifera venom with allergenic potential beyond carbohydrate-based reactivity. Clinical and Experimental Allergy, 42(6), 976-985. https://doi.org/10.1111/j.1365-2222.2012.03966.x

Jakob, T., Köhler, J., Blank, S., Spillner, E., Magnusson, U., Lidholm, J. & Huss-Marp, J. (2012). Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant-negative patients with bee venom allergy. Journal of Allergy and Clinical Immunology, 130(1), 276-278. https://doi.org/10.1016/j.jaci.2012.03.048

Michel, Y., Ginglinger, H., Blank, S., McIntyre, M., Ollert, M., Cifuentes, L. & Spillner, E. (2012). The putative serine protease inhibitor Api m 6 from Apis Mellifera venom: Recombinant and structural evaluation. Journal of Investigational Allergology and Clinical Immunology, 22(7), 476-484.

Kötzler, M. P., Blank, S., Bantleon, F. I., Spillner, E. & Meyer, B. (2012). Donor substrate binding and enzymatic mechanism of human core α1,6-fucosyltransferase (FUT8). B B A - General Subjects, 1820(12), 1915-1925. https://doi.org/10.1016/j.bbagen.2012.08.018

Blank, S., Neu, C., Hasche, D., Bantleon, F. I., Jakob, T. & Spillner, E. (2013). Polistes species venom is devoid of carbohydrate-based cross-reactivity and allows interference-free diagnostics. The Journal of allergy and clinical immunology, 131(4), 1239-42. https://doi.org/10.1016/j.jaci.2012.10.047

Blank, S., Seismann, H., McIntyre, M., Ollert, M., Wolf, S., Bantleon, F. I. & Spillner, E. (2013). Vitellogenins Are New High Molecular Weight Components and Allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris Venom. P L o S One, 8(4). https://doi.org/10.1371/journal.pone.0062009

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