Department of Biological and Chemical Engineering

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 Department of Biological and Chemical Engineering Research Key areas in research & development Medical Biotechnology Research Groups Organoid and Imaging Biotechnology Publications

Publications

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Møller, J. V., Nissen, P. & Sørensen, T. L.-M. (2006). X-ray crystallographic structures of sarcoplasmic reticulum Ca2+-ATPase at the atomic level. In R. Grisshammer & S. K. Buchanan (Eds.), Structural biology of membrane proteins (pp. 288-306). Royal Society of Chemistry.
Sanchez-Weatherby, J., Sandy, J., Mikolajek, H., Lobley, C. M. C., Mazzorana, M., Kelly, J., Preece, G., Littlewood, R. & Sørensen, T. L. M. (2019). VMXi: a fully automated, fully remote, high-flux in situ macromolecular crystallography beamline. Journal of Synchrotron Radiation, 26(Part 1), 291-301. https://doi.org/10.1107/S1600577518015114
Bell, J. S., Hayes, S., Whitford, C., Sanchez-Weatherby, J., Shebanova, O., Terrill, N. J., Sørensen, T. L. M., Elsheikh, A. & Meek, K. M. (2022). Tropocollagen springs allow collagen fibrils to stretch elastically. Acta Biomaterialia, 142, 185-193. https://doi.org/10.1016/j.actbio.2022.01.041
Abass, A., Hayes, S., White, N., Sorensen, T. & Meek, K. M. (2015). Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution. Journal of the Royal Society. Interface, 12(104), 20140717. https://doi.org/10.1098/rsif.2014.0717
Møller, J. V., Nissen, P., Sørensen, T. L.-M. & le Maire, M. (2005). Transport mechanism of the sarcoplasmic reticulum Ca2+ATPase pump. Curr. Op. Struct. Biol., 15, 387-393.
Hayes, S., White, T., Boote, C., Kamma-Lorger, C. S., Bell, J., Sorenson, T., Terrill, N., Shebanova, O. & Meek, K. M. (2017). The structural response of the cornea to changes in stromal hydration. Journal of the Royal Society. Interface, 14(131), Article 20170062. https://doi.org/10.1098/rsif.2017.0062
Hayes, S., Lewis, P., Islam, M. M., Doutch, J., Sorensen, T., White, T., Griffith, M. & Meek, K. M. (2015). The structural and optical properties of type III human collagen biosynthetic corneal substitutes. Acta Biomaterialia, 25, 121-30. https://doi.org/10.1016/j.actbio.2015.07.009
Bell, J. S., Hayes, S., Whitford, C., Sanchez-Weatherby, J., Shebanova, O., Vergari, C., Winlove, C. P., Terrill, N., Sorensen, T., Elsheikh, A. & Meek, K. M. (2018). The hierarchical response of human corneal collagen to load. Acta Biomaterialia, 65, 216-225. https://doi.org/10.1016/j.actbio.2017.11.015
Andersen, J. P. & Sørensen, T. (1996). Site-directed mutagenesis studies of energy coupling in the sarcoplasmic reticulum Ca(2+)-ATPase. Biochimica et biophysica acta. Bioenergeticss, 1275(1-2), 118-22.
Andersen, J. P., Sørensen, T. & Vilsen, B. (1997). Site-directed mutagenesis analysis of the role of the M5S5 sector of the sarcoplasmic reticulum Ca(2+)-ATPase. Annals of the New York Academy of Sciences, 834, 333-8.
Pijanka, J. K., Coudrillier, B., Ziegler, K., Sorensen, T., Meek, K. M., Nguyen, T. D., Quigley, H. A. & Boote, C. (2012). Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae. Investigative Ophthalmology & Visual Science, 53(9), 5258-70. https://doi.org/10.1167/iovs.12-9705
Boote, C., Dooley, E. P., Gardner, S. J., Kamma-Lorger, C. S., Hayes, S., Nielsen, K., Hjortdal, J., Sørensen, T. L.-M., Terrill, N. J. & Meek, K. M. (2013). Quantification of collagen ultrastructure after penetrating keratoplasty - implications for corneal biomechanics. PLoS One, 8(7), e68166. https://doi.org/10.1371/journal.pone.0068166
Hjorth-Jensen, S. J., Oksanen, E., Nissen, P. & Sørensen, T. L. M. (2020). Prospects for membrane protein crystals in NMX. In P. C. E. Moody (Ed.), Neutron Crystallography in Structural Biology (pp. 47-68). Elsevier. https://doi.org/10.1016/bs.mie.2019.11.019
Møller, J. V., Nissen, P. & Sørensen, T. L.-M. (2004). Phosphoryl Transfer and Calcium Ion Occlusion in the Calcium Pump. Science, 304, 1672-1675.
Antaloae, A. V., Montigny, C., le Maire, M., Watson, K. A. & Sørensen, T. L.-M. (2013). Optimisation of recombinant production of active human cardiac SERCA2a ATPase. PLoS One, 8(8), e71842. https://doi.org/10.1371/journal.pone.0071842
Sorensen, T. L.-M., McAuley, K. E., Flaig, R. & Duke, E. M. H. (2006). New light for science: synchrotron radiation in structural medicine. Trends in Biotechnology, 24(11), 500-8. https://doi.org/10.1016/j.tibtech.2006.09.006
Sorensen, T., Vilsen, B. & Andersen, J. P. (1997). Mutation Lys758 --> Ile of the sarcoplasmic reticulum Ca2+-ATPase enhances dephosphorylation of E2P and inhibits the E2 to E1Ca2 transition. Journal of Biological Chemistry, 272(48), 30244-53.
Jensen, A.-M. L., Sørensen, T. L.-M., Olesen, C., Møller, J. V. & Nissen, P. (2006). Modulatory and catalytic modes of ATP binding by the calcium pump. E M B O Journal, 25(11), 2305-2314.
Morth, J. P., Sørensen, T. L.-M. & Nissen, P. (2006). Membrane's Eleven: heavy-atom derivatives of membrane-protein crystals. Acta Crystallographica, D62(8), 877-882.
Sørensen, T. L. M., Hjorth-Jensen, S. J., Oksanen, E., Andersen, J. L., Olesen, C., Møller, J. V. & Nissen, P. (2018). Membrane-protein crystals for neutron diffraction. Acta crystallographica Section D: Structural biology , 74(Pt 12), 1208-1218. https://doi.org/10.1107/S2059798318012561
Sørensen, T. L.-M., Clausen, J. D., Jensen, A.-M. . L., Vilsen, B., Møller, J. V., Andersen, J. P. & Nissen, P. (2004). Localization of a K+-binding Site Involved in Dephosphorylation of the Sarcoplasmic Reticulum Ca2+-ATPase. Journal of Biological Chemistry, 279(45), 46355-46358.
Andersen, J. P., Sørensen, T. L.-M., Povlsen, K. & Vilsen, B. (2001). Importance of transmembrane segment M3 of the sarcoplasmic reticulum Ca2+-ATPase for control of the gateway to the Ca2+-sites. Journal of Biological Chemistry, 276, 23312-23321.
Sørensen, T. L.-M. & Andersen, J. P. (2000). Importance of stalk segment S5 for intramolecular communication in the sarcoplasmic reticulum Ca2+-ATPase. Journal of Biological Chemistry, 275, 28954-28961.
Hall, J. P., Gurung, S. P., Henle, J., Poidl, P., Andersson, J., Lincoln, P., Winter, G., Sorensen, T., Cardin, D. J., Brazier, J. A. & Cardin, C. J. (2017). Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects. Chemistry: A European Journal, 23(21), 4981-4985. https://doi.org/10.1002/chem.201605508
Sørensen, T. L.-M., Dupont, Y., Vilsen, B. & Andersen, J. P. (2000). Fast kinetic analysis of conformational changes in mutants of the Ca2+-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry, 275, 5400-5408. https://doi.org/10.1074/jbc.275.8.5400
Coudrillier, B., Pijanka, J., Jefferys, J., Sorensen, T., Quigley, H. A., Boote, C. & Nguyen, T. D. (2015). Effects of age and diabetes on scleral stiffness. Journal of Biomechanical Engineering, 137(7). https://doi.org/10.1115/1.4029986
Dyla, M., Terry, D., Kjærgaard, M., Sørensen, T. L.-M., Andersen, J. L., Andersen, J. P., Knudsen, C. R., Altman, R., Nissen, P. & Blanchard, S. (2017). Dynamics of P-type ATPase transport cycle revealed by single-molecule FRET. Nature, 551(7680), 346-351. https://doi.org/10.1038/nature24296
Hayes, S., Khan, S., Boote, C., Kamma-Lorger, C. S., Dooley, E., Lewis, J., Hawksworth, N., Sorensen, T., Daya, S. & Meek, K. M. (2012). Depth profile study of abnormal collagen orientation in keratoconus corneas. JAMA Ophthalmology, 130(2), 251-2. https://doi.org/10.1001/archopthalmol.2011.1467
Pijanka, J. K., Spang, M. T., Sorensen, T., Liu, J., Nguyen, T. D., Quigley, H. A. & Boote, C. (2015). Depth-dependent changes in collagen organization in the human peripapillary sclera. PLoS One, 10(2), e0118648. https://doi.org/10.1371/journal.pone.0118648
Olesen, C., Sørensen, T. L.-M., Nielsen, R. C., Møller, J. V. & Nissen, P. (2004). Dephosphorylation of the Calcium Pump Coupled to Counterion Occlusion. Science, 306, 2251-2255.
Hall, J. P., Keane, P. M., Beer, H., Buchner, K., Winter, G., Sorensen, T. L., Cardin, D. J., Brazier, J. A. & Cardin, C. J. (2016). Delta chirality ruthenium 'light-switch' complexes can bind in the minor groove of DNA with five different binding modes. Nucleic Acids Research, 44(19), 9472-9482. https://doi.org/10.1093/nar/gkw753
Morth, J. P., Pedersen, B. P., Toustrup-Jensen, M. S., Sørensen, T. L.-M., Petersen, J., Andersen, J. P., Vilsen, B. & Nissen, P. (2007). Crystal structure of the sodium-potassium pump. Nature, 450(7172), 1043-1049. https://doi.org/10.1038/nature06419
Sørensen, T. L.-M., Olesen, C., Jensen, A.-M. L., Møller, J. V. & Nissen, P. (2006). Crystals of sarcoplasmic reticulum Ca2+-ATPase. Journal of Biotechnology, 124(4), 704-716.
Jidenko, M., Nielsen, R. C., Sørensen, T. L.-M., Møller, J. V., le Maire, M., Nissen, P. & Jaxel, C. (2005). Crystallization of a mammalian membrane protein overexpressed in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences (PNAS), 102(33), 11687-91. https://doi.org/10.1073/pnas.0503986102
Coudrillier, B., Pijanka, J., Jefferys, J., Sorensen, T., Quigley, H. A., Boote, C. & Nguyen, T. D. (2015). Collagen structure and mechanical properties of the human sclera: analysis for the effects of age. Journal of Biomechanical Engineering, 137(4), 041006. https://doi.org/10.1115/1.4029430
Kamma-Lorger, C. S., Boote, C., Hayes, S., Moger, J., Burghammer, M., Knupp, C., Quantock, A. J., Sorensen, T., Di Cola, E., White, N., Young, R. D. & Meek, K. M. (2010). Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology, 169(3), 424-30. https://doi.org/10.1016/j.jsb.2009.11.004
Pijanka, J. K., Kimball, E. C., Pease, M. E., Abass, A., Sorensen, T., Nguyen, T. D., Quigley, H. A. & Boote, C. (2014). Changes in scleral collagen organization in murine chronic experimental glaucoma. Investigative Ophthalmology & Visual Science, 55(10), 6554-64. https://doi.org/10.1167/iovs.14-15047
Boote, C., Palko, J. R., Sorensen, T., Mohammadvali, A., Elsheikh, A., Komáromy, A. M., Pan, X. & Liu, J. (2016). Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation. Molecular Vision, 22, 503-17.
Mazzorana, M. & Sørensen, T. L. M. (2019). Calcium-Induced Protein Folding in Calumenin and Calmodulin. In C. Heizmann (Ed.), Calcium-Binding Proteins of the EF-Hand Superfamily (Vol. 1929, pp. 517-537). Humana Press. https://doi.org/10.1007/978-1-4939-9030-6_32
Mazzorana, M., Hussain, R. & Sorensen, T. (2016). Ca-Dependent Folding of Human Calumenin. PLoS One, 11(3), e0151547. Article e0151547. https://doi.org/10.1371/journal.pone.0151547
Picard, M., Jensen, A.-M. L., Sørensen, T. L.-M., Champeil, P., Møller, J. V. & Nissen, P. (2007). Ca(2+) versus Mg(2+) Coordination at the Nucleotide-binding site of the Sarcoplasmic Reticulum Ca(2+)-ATPase. Journal of Molecular Biology, 368(1), 1-7.
Aller, P., Sanchez-Weatherby, J., Foadi, J., Winter, G., Lobley, C. M. C., Axford, D., Ashton, A. W., Bellini, D., Brandao-Neto, J., Culurgioni, S., Douangamath, A., Duman, R., Evans, G., Fisher, S., Flaig, R., Hall, D. R., Lukacik, P., Mazzorana, M., McAuley, K. E. ... Walsh, M. A. (2015). Application of in situ diffraction in high-throughput structure determination platforms. Methods in molecular biology (Clifton, N.J.), 1261, 233-53. https://doi.org/10.1007/978-1-4939-2230-7_13
Morgan, S. R., Dooley, E. P., Hocking, P. M., Inglehearn, C. F., Ali, M., Sorensen, T. L.-M., Meek, K. M. & Boote, C. (2013). An x-ray scattering study into the structural basis of corneal refractive function in an avian model. Biophysical Journal, 104(12), 2586-94. https://doi.org/10.1016/j.bpj.2013.04.053
Mazzorana, M., Sanchez-Weatherby, J., Sandy, J., Lobley, C. M. C. & Sorensen, T. (2014). An evaluation of adhesive sample holders for advanced crystallographic experiments. Acta crystallographica Section D: Structural biology , 70(Pt 9), 2390-400. https://doi.org/10.1107/S1399004714014370
Lobley, C. M. C., Sandy, J., Sanchez-Weatherby, J., Mazzorana, M., Krojer, T., Nowak, R. P. & Sorensen, T. L. (2016). A generic protocol for protein crystal dehydration using the HC1b humidity controller. Acta crystallographica Section D: Structural biology, 72(Pt 5), 629-40. https://doi.org/10.1107/S2059798316003065
Revised 13.11.2025
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Thomas Lykke-Møller Sørensen