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Department of Biological and Chemical Engineering

Publications

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Merrild, A., Svenningsen, T., Chevrette, M. & Tørring, T. (2025). Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides. Angewandte Chemie International Edition, Article e202425134. Advance online publication. https://doi.org/10.1002/anie.202425134

Zdouc, M. M., Blin, K., Louwen, N. L. L., Navarro, J., Loureiro, C., Bader, C. D., Bailey, C. B., Barra, L., Booth, T. J., Bozhüyük, K. A. J., Cediel-Becerra, J. D. D., Charlop-Powers, Z., Chevrette, M. G., Chooi, Y. H., D'Agostino, P. M., de Rond, T., Del Pup, E., Duncan, K. R., Gu, W. ... Medema, M. H. (2025). MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration. Nucleic Acids Research, 53(D1), D678-D690. https://doi.org/10.1093/nar/gkae1115

Borcher Møller, S. L., Rasmussen, M. H., Li, J., Svenningsen, E. B., Wørmer, G. J., Tørring, T. & Poulsen, T. B. (2024). The Biological Activities of Polyether Ionophore Antibiotic Routiennocin is Independent of Absolute Stereochemistry. ChemBioChem, 25(7), Article e202400013. https://doi.org/10.1002/cbic.202400013

Hougaard, R. F., Andersen, F. D. & Tørring, T. (2024). Scaffolding scientific inquiry: Adapting Tiny Earth for engaging high school students and their teachers in authentic research. Abstract from The Nordic conference on Science Education Research, NFSUN 2024, Reykjavik, Iceland.

Larsen, C. K., Lindquist, P., Rosenkilde, M., Madsen, A. R., Haselmann, K., Glendorf, T., Olesen, K., Kodal, A. L. B. & Tørring, T. (2024). Using LanM Enzymes to Modify Glucagon-Like Peptides 1 and 2 in E. coli. ChemBioChem, 25(13), Article e202400201. https://doi.org/10.1002/cbic.202400201

Busk, M., Eggertsen, P. P., Overgaard, J., Horsman, M. R., Tørring, T., Jacobsen, K. M. & Poulsen, T. B. (2023). In Vitro Characterization of the Bacteria-derived Hypoxia-selective Cytotoxin BE-₄₃₅₄₇. Anticancer Research, 43(12), 5319-5329. https://doi.org/10.21873/anticanres.16735

Terlouw, B. R., Blin, K., Navarro-Muñoz, J. C., Avalon, N. E., Chevrette, M. G., Egbert, S., Lee, S., Meijer, D., Recchia, M. J. J., Reitz, ZL., van Santen, JA., Selem-Mojica, N., Tørring, T., Zaroubi, L., Alanjary, M., Aleti, G., Aguilar, C., Al-Salihi, S. A. A., Augustijn, HE. ... Medema, MH. (2023). MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters. Nucleic Acids Research, 51(D1), D603-D610. Article gkac1049. https://doi.org/10.1093/nar/gkac1049

Wollesen, M., Mikkelsen, K., Tvilum, M. S., Vestergaard, M., Wang, M., Meyer, R. L., Ingmer, H., Poulsen, T. & Tørring, T. (2023). Polyether Ionophore Antibiotics Target Drug-Resistant Clinical Isolates, Persister Cells, and Biofilms. Microbiology Spectrum, 11(4), Article e0062523. https://doi.org/10.1128/spectrum.00625-23

Andersen, F. D., Pedersen, K. D., Wilkens Juhl, D., Mygind, T., Chopin, P., B. Svenningsen, E., Poulsen, T. B., Braad Lund, M., Schramm, A., Gotfredsen, C. H. & Tørring, T. (2022). Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. Journal of Natural Products, 85(6), 1514-1521. https://doi.org/10.1021/acs.jnatprod.2c00065

Svenningsen, E. B., Ottosen, R. N., Jørgensen, K. H., Nisavic, M., Larsen, C. K., Hansen, B. K., Wang, Y., Lindorff-Larsen, K., Tørring, T., M. Hacker, S. & Poulsen, T. (2022). The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21. Poster session presented at EMBO Chemical Biology, Heidelberg, Germany.

Svenningsen, E. B., Ottosen, R. N., Jørgensen, K. H., Nisavic, M., Larsen, C. K., Hansen, B. K., Wang, Y., Lindorff-Larsen, K., Tørring, T., Hacker, S. M., Palmfeldt, J. & Poulsen, T. B. (2022). The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21. RSC Chemical Biology, 3(10), 1216-1229. https://doi.org/10.1039/d2cb00161f

Garcia Soriano, D. A., Andersen, F. D., Nygaard, J. V. & Tørring, T. (2021). ColFeatures: Automated data extraction and classification of bacterial colonies. bioRxiv. https://doi.org/10.1101/2021.05.27.445853

Lin, S., Liu, H., Svenningsen, E. B., Wollesen, M., Jacobsen, K. M., Andersen, F. D., Moyano-Villameriel, J., Pedersen, C. N., Nørby, P., Tørring, T. & Poulsen, T. B. (2021). Expanding the antibacterial selectivity of polyether ionophore antibiotics through diversity-focused semisynthesis. Nature Chemistry, 13(1), 47-55. https://doi.org/10.1038/s41557-020-00601-1

Petermeier, P., Fortuna, C., M. Hübschmann, K., Nahuel Bidart Costoya, G., Tørring, T., Teze, D., Welner, D. H. & Kara, S. (2021). Exploring the in Vitro Operating Window of Glycosyltransferase PtUGT1 from Polygonum tinctorium for a Biocatalytic Route to Indigo Dye. ACS Sustainable Chemistry & Engineering, 9(25), 8497-8506. https://doi.org/10.1021/acssuschemeng.1c01536

Hansen, B. K., Larsen, C. K., Nielsen, J. T., Svenningsen, E. B., Van, L. B., Jacobsen, K. M., Bjerring, M., Flygaard, R. K., Jenner, L. B., Nejsum, L. N., Brodersen, D. E., Mulder, F. A. A., Tørring, T. & Poulsen, T. B. (2020). Structure and Function of the Bacterial Protein Toxin Phenomycin. Structure, 28(5), 528-539.e9. https://doi.org/10.1016/j.str.2020.03.003

Hjerrild, P., Tørring, T. & Poulsen, T. B. (2020). Dehydration reactions in polyfunctional natural products. Natural Product Reports, 37(8), 1043-1064. https://doi.org/10.1039/d0np00009d

Mortensen, M. R., Skovsgaard, M. B., Märcher, A., Andersen, V. L., Palmfeldt, J., Nielsen, T. B., Tørring, T., Laursen, N. S., Andersen, K. R., Kjems, J. & Gothelf, K. V. (2020). Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling. Bioconjugate Chemistry, 31(5), 1295-1300. https://doi.org/10.1021/acs.bioconjchem.0c00151

Lin, S., Liu, H., Svenningsen, E. B., Pedersen, C., Nørby, P., Tørring, T. & Poulsen, T. (2019). Diversity Focused Semisyntheses of Tetronate Polyether Ionophores. ChemRxiv. https://chemrxiv.org/articles/Diversity_Focused_Semisyntheses_of_Tetronate_Polyether_Ionophores/8299715

Villadsen, N. L., Hansen, B. K., Svenningsen, E. B., Jørgensen, K. H., Tørring, T. & Poulsen, T. B. (2018). Stendomycin and Pantomycin Are Identical Natural Products: Preparation of a Functionalized Bioactive Analogue. Journal of Organic Chemistry, 83(13), 7303-7308. https://doi.org/10.1021/acs.joc.8b00553

Tørring, T., Shames, S. R., Cho, W., Roy, C. R. & Crawford, J. M. (2017). Acyl Histidines: New N-Acyl Amides from Legionella pneumophila. ChemBioChem, 18(7), 638-646. https://doi.org/10.1002/cbic.201600618

Trads, J. B., Tørring, T. & Gothelf, K. V. (2017). Site-Selective Conjugation of Native Proteins with DNA. Accounts of Chemical Research, 50(6), 1367-1374. https://doi.org/10.1021/acs.accounts.6b00618

Villadsen, N. L., Jacobsen, K. M., Keiding, U., Tørring, T. & Poulsen, T. (2017). Synthesis of ent-BE-43547A1 Reveals a Potent Hypoxia-Selective Anticancer Agent and Uncovers the Biosynthetic Origin of the APDCLD Natural Products. Synfact, 2017(7), A107-111. https://doi.org/10.1055/s-0036-1590288

Villadsen, N. L., Jacobsen, K. M., Keiding, U., Weibel, E. T., Christiansen, B., Vosegaard, T., Bjerring, M., Jensen, F., Johannsen, M., Tørring, T. & Poulsen, T. (2017). Synthesis of ent-BE-43547A₁ reveals a potent hypoxia-selective anticancer agent and uncovers the biosynthetic origin of the APD-CLD natural products. Nature Chemistry, 9(3), 264-272. https://doi.org/10.1038/nchem.2657

Villadsen, N. L., Jacobsen, K. M., Tørring, T. & Poulsen, T. (2017). Unikke naturstoffer dræber resistente cancerceller. Dansk Kemi, 98(3), 10-13. http://ipaper.ipapercms.dk/TechMedia/DanskKemi/2017/3/

Kodal, A. L. B., Rosen, C. B., Mortensen, M. R., Tørring, T. & Gothelf, K. V. (2016). DNA-Templated Introduction of an Aldehyde Handle in Proteins. ChemBioChem, 17(14), 1338-1342. https://doi.org/10.1002/cbic.201600254

Schaffert, D. H., Okholm, A. H., Sørensen, R. S., Nielsen, J., Tørring, T., Rosen, C. B., Kodal, A. L. B., Mortensen, M. R., Gothelf, K. V. & Kjems, J. (2016). Intracellular Delivery of a Planar DNA Origami Structure by the Transferrin-Receptor Internalization Pathway. Small, 12(19), 2634-2640. https://doi.org/10.1002/smll.201503934

Rosen, C. B., Tørring, T. & Gothelf, K. V. (2014). DNA-Templated Synthesis: in Nucleic Acid Nanotechnology, Nucleic Acids and Molecular Biology. In J. Kjems, E. Ferapontova & K. V. Gothelf (Eds.), Nucleic Acid Nanotechnology (Vol. 29). Springer. https://doi.org/10.1007/978-3-642-38815-6_7

Rosen, C. B., Kodal, A. L. B., Nielsen, J. S., Schaffert, D. H., Scavenius, C., Okholm, A. H., Voigt, N. V., Enghild, J. J., Kjems, J., Tørring, T. & Gothelf, K. V. (2014). Template-directed covalent conjugation of DNA to native antibodies, transferrin and other metal-binding proteins. Nature Chemistry, 6(9), 804-809. https://doi.org/10.1038/nchem.2003

Tørring, T., Helmig, S. W., Ogilby, P. R. & Gothelf, K. V. (2014). Singlet Oxygen in DNA Nanotechnology. Accounts of Chemical Research, 47(6), 1799-1806. https://doi.org/10.1021/ar500034y

Tørring, T. & Gothelf, K. V. (2013). DNA nanotechnology: a curiosity or a promising technology? F1000Prime Reports, 5(14). https://doi.org/10.12703/P5-14

Funder, E. D., Jensen, A. B., Tørring, T., Kodal, A. L. B., Azcargorta, A. R. & Gothelf, K. V. (2012). Synthesis of Dopamine and Serotonin Derivatives for Immobilization on a Solid Support. Journal of Organic Chemistry, 77(7), 3134-3142. https://doi.org/10.1021/jo2025477

Jahn, K., Tørring, T., Voigt, N. V., Sørensen, R. S., Kodal, A. L. B., Andersen, E. S., Gothelf, K. V. & Kjems, J. (2011). Functional Patterning of DNA Origami by Parallel Enzymatic Modification. Bioconjugate Chemistry, 22(4), 819-823. https://doi.org/10.1021/bc2000098

Jahn, K., Olsen, E. M., Nielsen, M. M., Tørring, T., Mohammadzadegan, R., Andersen, E. S., Gothelf, K. V. & Kjems, J. (2011). Site-Specific Chemical Labeling of Long RNA Molecules. Bioconjugate Chemistry, 22(1), 95-100. https://doi.org/10.1021/bc100422k

Tørring, T. (2011). Controlling Function and Structure with DNA.

Tørring, T., Voigt, N. V., Nangreave, J., Yan, H. & Gothelf, K. V. (2011). DNA origami: a quantum leap for self-assembly of complex structures. Chemical Society Reviews, 40. https://doi.org/10.1039/c1cs15057j

Zhang, Z., Olsen, E. M., Kryger, M., Voigt, N. V., Tørring, T., Gültekin, E., Nielsen, M., MohammadZadegan, R., Andersen, E. S., Nielsen, M. M., Kjems, J., Birkedal, V. & Gothelf, K. V. (2011). A DNA tile actuator with eleven discrete states. Angewandte Chemie International Edition, 50(17), 3983-7. https://doi.org/10.1002/anie.201007642

Liu, H., Tørring, T., Dong, M., Rosen, C. B., Besenbacher, F. & Gothelf, K. V. (2010). DNA-templated covalent coupling of G4 PAMAM dendrimers. Journal of the American Chemical Society, 132(51), 18054-6. https://doi.org/10.1021/ja109677n

Tørring, T., Toftegaard, R., Arnbjerg, J., Ogilby, P. R. & Gothelf, K. V. (2010). Reversible pH-Regulated Control of Photosensitized Singlet Oxygen Production Using a DNA i-Motif. Angewandte Chemie International Edition, 49, 7923-7925.

Voigt, N. V., Tørring, T. & Gothelf, K. V. (2010). DNA-Origami. Dansk Kemi, 91(8), 14-17.

Voigt, N. V., Tørring, T., Rotaru, A., Jacobsen, M. F., Ravnsbæk, J. B., Subramani, R., Mamdouh, W., Kjems, J., Mokhir, A., Besenbacher, F. & Gothelf, K. V. (2010). Single-molecule chemical reactions on DNA origami. Nature Nanotechnology, 5(3), 200-203. https://doi.org/10.1038/nnano.2010.5

Revised 16.01.2025