Conventional antibiotic treatment is inadequate for eradication of bacterial biofilm infections as only sublethal concentrations can be administered safely to patients. A potential solution to this challenge is targeted drug delivery.
In my PhD study, we tailored an aptamer-targeted liposomal drug delivery system that accumulates in S. aureus biofilm and delivers a combination of antibiotics locally inside the biofilm. In this presentation I will show the results and discuss what we learned from the study.