Department of Biological and Chemical Engineering

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 Department of Biological and Chemical Engineering Research Key areas in research & development Industrial Biotechnology Research Groups Multiscale Microbial Engineering Research

Research

Some of our current working topic include:

  • Design of genetic circuits to autonomously control physiological traits relevant for the biomanufacturing process.
  • Design of auto inducible replicons for high yield production of plasmid for gene therapy and mRNA production.
  • Streamlining cell factories for improved robustness under large-scale production environments.
High cell-density culture in batch mode of engineered E. coli expressing the green fluorescence protein (GFP). The engineered cells display a very low overflow metabolism. Using 100 g/L glucose allows attaining high cell-densities and GFP expression, while only small amounts of acetate are accumulated. This concept has also been demonstrated for plasmid DNA vaccines production. Picture: Alvaro R. Lara
Revised 07.02.2024