An incredible array of natural products are made throughout the natural world. The potent biological activity of many of these compounds has led to their widespread use across medicine and agriculture, where they have been transformative to human health. For example, the majority of clinically used antibiotics are made by Actinobacteria. However, the role of many bacterial natural products in nature is poorly understood, especially for prolific producers, such as Streptomyces or Pseudomonas species. I will discuss our approaches to use genomic data to prioritise the discovery of pathways to bioactive natural products, which led to the discovery of an antibiotic pathway in a plant pathogen. The structure, mechanism of action and biological function of the molecule will be described. In addition, I will discuss our use of pan-genomic data to identify Pseudomonas natural products that can suppress plant and human pathogens.